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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제3호
- 발행연도
- 2019.1
- 수록면
- 429 - 440 (12page)
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초록· 키워드
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Several studies have attempted to identify factors associated with longevity and maintenance of health in centenarians. In this study, we analyzed and compared the gut microbiota of centenarians in longevity villages with the elderly and adults in the same region and urbanized towns. Fecal samples were collected from centenarians, elderly, and young adults in longevity villages, and the gut microbiota sequences of elderly and young adults in urbanized towns of Korea were obtained from public databases. The relative abundance of Firmicutes was found to be considerably higher in subjects from longevity villages than those from urbanized towns, whereas Bacteroidetes was lower. Age-related rearrangement of gut microbiota was observed in centenarians, such as reduced proportions of Faecalibacterium and Prevotella, and increased proportion of Escherichia, along with higher abundances of Akkermansia, Clostridium, Collinsella, and uncultured Christensenellaceae. Gut microbiota of centenarians in rehabilitation hospitals were also different to those residing at home. These differences could be due to differences in diet patterns and living environments. In addition, phosphatidylinositol signaling system, glycosphingolipid biosynthesis, and various types of N-glycan biosynthesis were predicted to be higher in the gut microbiota of centenarians (corrected p < 0.05). These three metabolic pathways of gut microbiota can be associated with the immune status and healthy gut environment of centenarians. Although further studies are necessary to validate the function of microbiota between groups, this study provides valuable information on centenarians’ gut microbiota.
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참고문헌 (57)
참고문헌 신청
Willcox DC / 2008 / They really are that old: a validation study of centenarian prevalence in Okinawa / J. Gerontol. A, Biol. Sci. Med. Sci 63:338~349
Smith DW / 1997 / Centenarians : human longevity outliers / Gerontologist 37:200~206
Bernstein AM / 2004 / First autopsy study of an Okinawan centenarian: absence of many age-related diseases / J. Gerontol. A, Biol. Sci. Med. Sci 59:1195~1199
Evert J / 2003 / Morbidity profiles of centenarians: survivors, delayers, and escapers / J. Gerontol. A, Biol. Sci. Med. Sci 58:232~237
Franceschi C / 2017 / Centenarians as a 21st century healthy aging model: A legacy of humanity and the need for a world-wide consortium (WWC100+) / Mech. Ageing Dev 165:55~58
Smith DW / 1997 / Centenarians : human longevity outliers / Gerontologist 37:200~206
Bernstein AM / 2004 / First autopsy study of an Okinawan centenarian: absence of many age-related diseases / J. Gerontol. A, Biol. Sci. Med. Sci 59:1195~1199
Evert J / 2003 / Morbidity profiles of centenarians: survivors, delayers, and escapers / J. Gerontol. A, Biol. Sci. Med. Sci 58:232~237
Franceschi C / 2017 / Centenarians as a 21st century healthy aging model: A legacy of humanity and the need for a world-wide consortium (WWC100+) / Mech. Ageing Dev 165:55~58
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