지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Numerous efforts are being made to develop an ideal dermal filler that should be bio-compatibility, nonimmunogenicity, long-lasting and biodegradable without a toxic secretion. Biomaterials of dermal fillers are hyaluronic acid filler, calcium filler, PMMA filler and collagen filler depending on the ingredient. Although hyaluronic acid (HA) is most widely used, it has shortages such as short shelf life and low mechanical strength compare to extracellular matrix (ECM). The cartilage ECM composed of collagen type II, proteoglycans, glycosaminoglycans (GAGs) and in a minor part with glycoproteins. In this study, we developed a cartilage ECM injectable filler capable of improving biocompatibility and longevity compared with hyaluronic acid (HA) fillers. The ECM hydrogel was cross-linked by the reaction of N- (3-Dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) for mechanical enhancement. Prepared ECM filler was compared with cross-linked HA by butanediol diglycidyle ether (BDDE), which is the most widely used natural polymers for dermal filler. In the results, the articular cartilage ECM hydrogel has great potential as a dermal filler to improve the biophysical and biological performance.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Gilchrest BA / 1989 / Skin aging and photoaging : an overview / Journal of the American Academy of Dermatology 21(3):610~613
Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Archives of dermatology 138(11):1462~1470
Fisher GJ / 1997 / Pathophysiology of premature skin aging induced by ultraviolet light / New England Journal of Medicine 337(20):1419~1429
Helfrich YR / 2008 / Overview of skin aging and photoaging / Dermatology nursing 20(3):177
Newton VL / 2015 / Skin aging : molecular pathology, dermal remodelling and the imaging revolution / G Ital Dermatol Venereol 150(6):665~674
Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Archives of dermatology 138(11):1462~1470
Fisher GJ / 1997 / Pathophysiology of premature skin aging induced by ultraviolet light / New England Journal of Medicine 337(20):1419~1429
Helfrich YR / 2008 / Overview of skin aging and photoaging / Dermatology nursing 20(3):177
Newton VL / 2015 / Skin aging : molecular pathology, dermal remodelling and the imaging revolution / G Ital Dermatol Venereol 150(6):665~674
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