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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The microencapsulation of nifedipine (NF) with 4 wt% of poly(ε-caprolactone) (PCL)/polyvinylpyrollidone (PVP) or PCL/polyethylene glycol (PEG) was carried out by solvent evaporation method in oil in water emulsion system to investigate the effect of PVP and PEG addition on drug release behavior of the microcapsules. The PVA (emulsifier) concentration of 1.0 wt% was chosen for the formation of PCL capsule having an average size of 154 ± 25 μm due to nearly spherical shape with a narrow size distribution. As PCL/PVP and PCL/PEG ratios were raised from 10/0 to 6/4, the capsule size increased gradually from 154 ± 25 μm to 236 ± 32 μm and 248 ± 56 μm, respectively. The drug release rate of PCL/PVP and PCL/PEG capsules increased dramatically from 0 to 4 h at the beginning and then reached the plateau region from 20 h. As the concentration of PVP or PEG increased, the amount of drug release increased, suggesting that the larger capsule size was attributed to the higher drug content. However, the drug release behavior remained almost constant. The PCL capsules exhibited no evidence of causing cell lysis or toxicity regardless of NF loading, implying that the microcapsules are clinically suitable for use as drug delivery systems.
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참고문헌 (23)
참고문헌 신청
S. Kang / 2015 / Coreshell polymeric microcapsules with superior thermal and solvent stability / ACS Appl. Mater. Interfaces 7:10952~10956
N. V. N. Jyothi / 2010 / Microencapsulation technique, factors influencing encapsulation efficiency / J. Microencapsulation 27:187~197
박수진 / 2004 / 토코페롤을 함유하는 생분해성 폴리(e-카프로락톤) 마이크로캡슐의 제조 및 방출 특성 / 폴리머 28(2):103~110
박수진 / 2003 / 에리트로마이신을 함유한 생분해성 폴리가프로락톤/폴리(에틸렌 옥사이드) 마이크로캡슐의 제조 및 특성 / 폴리머 27(5):449~457
장미경 / 2004 / 수용성 키토산으로 제조한 미세구의 분해성과 약물 방출 거동 / 폴리머 28(4):291~297
N. V. N. Jyothi / 2010 / Microencapsulation technique, factors influencing encapsulation efficiency / J. Microencapsulation 27:187~197
박수진 / 2004 / 토코페롤을 함유하는 생분해성 폴리(e-카프로락톤) 마이크로캡슐의 제조 및 방출 특성 / 폴리머 28(2):103~110
박수진 / 2003 / 에리트로마이신을 함유한 생분해성 폴리가프로락톤/폴리(에틸렌 옥사이드) 마이크로캡슐의 제조 및 특성 / 폴리머 27(5):449~457
장미경 / 2004 / 수용성 키토산으로 제조한 미세구의 분해성과 약물 방출 거동 / 폴리머 28(4):291~297
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