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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background and Purpose Previous studies suggested increased visit-to-visit variability of total cholesterol (TC) is associated with stroke. This study aimed to investigate the associations of various lipids measurements variability and the risk of stroke and stroke type (ischemic and hemorrhagic stroke). Methods Fifty-one thousand six hundred twenty participants in the Kailuan Study without history of myocardial infarction, stroke, and cancer who underwent three health examinations during 2006 to 2010 were followed for incident stroke. Variability in TC, triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) measurements were measured using the coefficient of variation (CV), standard deviation (SD), variability independent of the mean (VIM), and average real variability (ARV). Results During a median of 6.04 years of follow-up, 1,189 incident stroke (1,036 ischemic and 160 hemorrhagic stroke) occurred. In the multivariable-adjusted model, the hazard ratio (HR) comparing participants in the highest versus lowest quartile of CV of HDL-C were 1.21 (95% confidence interval [CI], 1.02 to 1.45; P for trend=0.013) for ischemic stroke. The highest quartile of CV of LDL-C was associated with 2.17-fold risk of hemorrhagic stroke (HR, 2.17; 95% CI, 1.25 to 3.75; P for trend=0.002) compared with the lowest quartile. We did not observe any significant association between TC and triglycerides variability with any of stroke. Consistent results were obtained when calculating variability index using SD, VIM, or ARV. Conclusions These findings suggest the high visit-to-visit HDL-C and LDL-C variability were associated with an increased incidence of ischemic and hemorrhagic stroke, respectively.
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참고문헌 (34)
참고문헌 신청
Feigin VL / 2017 / Global burden of stroke / Circ Res 120:439~448
Wang W / 2017 / Trend of declining stroke mortality in China : reasons and analysis / Stroke Vasc Neurol 2:132~139
Feigin VL / 2016 / Prevention of stroke : a strategic global imperative / Nat Rev Neurol 12:501~512
Shahar E / 2003 / Plasma lipid profile and incident ischemic stroke : the Atherosclerosis Risk in Communities(ARIC)study / Stroke 34:623~631
Tirschwell DL / 2004 / Association of cholesterol with stroke risk varies in stroke subtypes and patient subgroups / Neurology 63:1868~1875
Wang W / 2017 / Trend of declining stroke mortality in China : reasons and analysis / Stroke Vasc Neurol 2:132~139
Feigin VL / 2016 / Prevention of stroke : a strategic global imperative / Nat Rev Neurol 12:501~512
Shahar E / 2003 / Plasma lipid profile and incident ischemic stroke : the Atherosclerosis Risk in Communities(ARIC)study / Stroke 34:623~631
Tirschwell DL / 2004 / Association of cholesterol with stroke risk varies in stroke subtypes and patient subgroups / Neurology 63:1868~1875
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