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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 58 - 65 (8page)
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Fat mass and obesityassociated (FTO) gene helps to regulate energy homeostasis in mammals by controlling energy expenditure. In addition, FTO functions in the regulation of obesity and adipogenic differentiation; however, a role in osteogenic differentiation is unknown. This study investigated the effects of FTO on osteogenic differentiation of C3H10T1/2 cells and the underlying mechanism. Expression of osteogenic and endoplasmic reticulum (ER) stress markers were characterized by reversetranscriptase polymerase chain reaction and western blotting. Alkaline phosphatase (ALP) staining was performed to assess ALP activity. BMP2 treatment increased mRNA expression of osteogenic genes and FTO. Overexpression of FTO increased expression of the osteogenic genes distalless homeobox5 (Dlx5) and runtrelated transcription factor 2 (Runx2). Activation of adenosine monophosphateactivated protein kinase (AMPK) increased FTO expression, and there was a positive feedback loop between FTO and pAMPK. pAMPK and FTO induced mild ER stress; however, tunicamycininduced severe ER stress suppressed FTO expression and AMPK activation. In summary, FTO induces osteogenic differentiation of C3H10T1/2 cells upon BMP2 treatment by inducing mild ER stress via a positive feedback loop with pAMPK. FTO expression and AMPK activation induce mild ER stress. By contrast, severe ER stress inhibits osteogenic differentiation by suppressing FTO expression and AMPK activation.
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참고문헌 (34)
참고문헌 신청
Canalis, E. / 2003 / Bone morphogenetic proteins, their antagonists, and the skeleton / Endocr. Rev 24:218~235
Fischer, J. / 2009 / Inactivation of the Fto gene protects from obesity / Nature 458:894~898
Frayling, T. M. / 2007 / A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity / Science 316:889~894
Gething, M. J. / 1992 / Protein folding in the cell / Nature 355:33~45
Ghemrawi, R. / 2018 / Endoplasmic reticulum stress in metabolic disorders / Cells 7:E63
Fischer, J. / 2009 / Inactivation of the Fto gene protects from obesity / Nature 458:894~898
Frayling, T. M. / 2007 / A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity / Science 316:889~894
Gething, M. J. / 1992 / Protein folding in the cell / Nature 355:33~45
Ghemrawi, R. / 2018 / Endoplasmic reticulum stress in metabolic disorders / Cells 7:E63
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