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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 323 - 330 (8page)
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Epigenetic events like DNA methylation and histone modification can alter heritable phenotypes. Zinc is required for the activity of various epigenetic enzymes, such as DNA methyltransferases (DNMTs), histone acetyltransferases (HATs), histone deacetylases (HDACs), and histone demethylases, which possess several zinc binding sites. Thus, the dysregulation of zinc homeostasis can lead to epigenetic alterations. Zinc homeostasis is regulated by Zinc Transporters (ZnTs), Zrt- and Irt-like proteins (ZIPs), and the zinc storage protein metallothionein (MT). Recent advances revealed that ZIPs modulate epigenetics. ZIP10 deficiency was found to result in reduced HATs, confirming its involvement in histone acetylation for rigid skin barrier formation. ZIP13 deficiency, which is associated with Spondylocheirodysplastic Ehlers–Danlos syndrome (SCD-EDS), increases DNMT activity, leading to dysgenesis of dermis via improper gene expressions. However, the precise molecular mechanisms remain to be elucidated. Future molecular studies investigating the involvement of zinc and its transporters in epigenetics are warranted.
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참고문헌 (77)
참고문헌 신청
안학준 / 2019 / Radiation-Induced CXCL12 Upregulation via Histone Modification at the Promoter in the Tumor Microenvironment of Hepatocellular Carcinoma / Molecules and Cells 42(7):530~545
Hussein Algahtani / 2017 / A novel mutation in the DNMT1 gene in a patient presenting with pure cerebellar ataxia / Journal of Genetic Medicine 14(2):71~74
Andreini, C. / 2006 / Counting the zincproteins encoded in the human genome / J. Proteome Res 5:196~201
Avvakumov, N. / 2007 / The MYST family of histone acetyltransferases and their intimate links to cancer / Oncogene 26:5395~5407
Berger, S. L. / 2009 / An operational definition of epigenetics / Genes Dev 23:781~783
Hussein Algahtani / 2017 / A novel mutation in the DNMT1 gene in a patient presenting with pure cerebellar ataxia / Journal of Genetic Medicine 14(2):71~74
Andreini, C. / 2006 / Counting the zincproteins encoded in the human genome / J. Proteome Res 5:196~201
Avvakumov, N. / 2007 / The MYST family of histone acetyltransferases and their intimate links to cancer / Oncogene 26:5395~5407
Berger, S. L. / 2009 / An operational definition of epigenetics / Genes Dev 23:781~783
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