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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 15 - 24 (10page)
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초록· 키워드
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The fruit of Chaenomeles sinensis (Thouin) Koehne (Chaenomelis Fructus) known as “Mo-Gua” in Korea has been commonly used in traditional medicine to treat inflammatory diseases, such as sore throat. However, its effect on bone metabolism has not been elucidated yet. Here, we examined the effect of Chaenomelis Fructus ethanol extract (CFE) on receptor activator of nuclear factor (NF)-κB ligand (RANKL)-mediated osteoclast differentiation and formation. CF-E considerably inhibited osteoclast differentiation and tartrate-resistant acid phosphatase-positive multinuclear cell formation from bone marrow-derived macrophages and osteoclast precursor cells in a dose-dependent manner. In addition, the formation of actin rings and resorption pits were significantly suppressed in CF-E-treated osteoclasts as compared with the findings in non-treated control cells. Consistent with these phenotypic inhibitory results, the expressions of osteoclast differentiation marker genes (Acp5, Atp6v0d2 , Oscar, CtsK, and Tm7sf4) and Nfatc1 , a pivotal transcription factor for osteoclastogenesis, were markedly decreased by CF-E treatment. The inhibitory effect of CF-E on RANKL-induced osteoclastogenesis was associated with the suppression of NFATc1 expression, not by regulation of mitogen-activated protein kinases and NF-κB activation but by the inactivation of phospholipase C gamma 1 and 2. These results indicate that CF-E has an inhibitory effect on osteoclast differentiation and formation, and they suggest the possibility of CF-E as a traditional therapeutic agent against bone-resorptive diseases, such as osteoporosis, rheumatoid arthritis, and periodontitis.
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참고문헌 (35)
참고문헌 신청
Matthew C. Walsh / 2006 / OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism / Annual Review of Immunology 24(1):33~63
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Matthew C. Walsh / 2014 / Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond / Frontiers in Immunology 5:511
Teruhito Yamashita / 2007 / NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1 / Journal of Biological Chemistry 282(25):18245~18253
S.E. Lee / 2002 / The phosphatidylinositol 3-Kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation / Bone 30(1):71~77
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Matthew C. Walsh / 2014 / Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond / Frontiers in Immunology 5:511
Teruhito Yamashita / 2007 / NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1 / Journal of Biological Chemistry 282(25):18245~18253
S.E. Lee / 2002 / The phosphatidylinositol 3-Kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation / Bone 30(1):71~77
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