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논문 기본 정보
- 자료유형
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- 저자정보
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- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제1호
- 발행연도
- 2020.1
- 수록면
- 27 - 37 (11page)
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Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but it has also been shown to exhibit strong antioxidative, anti-inflammatory, and neuroprotective effects. Here, we sought to investigate the effects of CAR on inflammation in the hippocampus and prefrontal cortex, as well as the molecular mechanisms underlying these effects. In our study, lipopolysaccharide was injected into the lateral ventricle of rats to induce memory impairment and neuroinflammation. Daily administration of CAR (25, 50, and 100 mg/kg) for 21 days improved recognition, discrimination, and memory impairments relative to untreated controls. CAR administration significantly attenuated expression of several inflammatory factors in the brain, including interleukin-1β, tumor necrosis factor-α, and cyclooxygenase-2. In addition, CAR significantly increased expression of brain-derived neurotrophic factor (BDNF) mRNA, and decreased expression of Toll-like receptor 4 (TLR4) mRNA. Taken together, these results show that CAR can improve memory impairment caused by neuroinflammation. This cognitive enhancement is due to the anti-inflammatory effects of CAR medicated by its regulation of BDNF and TLR4. Thus, CAR has significant potential as an inhibitor of memory degeneration in neurodegenerative diseases.
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참고문헌 (48)
참고문헌 신청
Zipp F / 2006 / The brain as a target of inflammation : common pathways link inflammatory and neurodegenerative diseases / Trends Neurosci 29:518~527
Kovaiou RD / 2007 / Age-related changes in immunity : implications for vaccination in the elderly / Expert Rev Mol Med 9:1~17
Liu WM / 2011 / Aging and impaired immunity to influenza viruses: implications for vaccine development / Hum Vaccin 7(Suppl):94~98
Widmann CN / 2014 / Long-term cerebral consequences of sepsis / Lancet Neurol 13:630~636
Cunningham C / 2015 / Co-morbidity and systemic inflammation as drivers of cognitive decline : new experimental models adopting a broader paradigm in dementia research / Alzheimers Res Ther 7:33~40
Kovaiou RD / 2007 / Age-related changes in immunity : implications for vaccination in the elderly / Expert Rev Mol Med 9:1~17
Liu WM / 2011 / Aging and impaired immunity to influenza viruses: implications for vaccine development / Hum Vaccin 7(Suppl):94~98
Widmann CN / 2014 / Long-term cerebral consequences of sepsis / Lancet Neurol 13:630~636
Cunningham C / 2015 / Co-morbidity and systemic inflammation as drivers of cognitive decline : new experimental models adopting a broader paradigm in dementia research / Alzheimers Res Ther 7:33~40
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