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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제18권 제2호
- 발행연도
- 2020.1
- 수록면
- 203 - 213 (11page)
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초록· 키워드
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Objective: We conducted a meta-analysis of randomized controlled trials to explore whether vitamin D supplementation is beneficial for symptom improvement in children with autism spectrum disorder. Methods: We systematically searched the PubMed database, EMBASE, Cochrane Library, Web of Science, Sino-Med, Wanfang Data, and China National Knowledge Infrastructure mainly up to September 2019. Using a fixed effects model, we calculated the standard mean difference with 95% confidence interval. Furthermore, we analyzed baseline serum 25-hydroxyvitamin D levels and outcome scores including the Social Responsiveness Scale and Child Autism Rating Scale scores after vitamin D supplementation. Results: There was no significant difference in baseline serum 25-hydroxyvitamin D levels among 203 children included from three studies in the meta-analysis. After vitamin D supplementation, the outcome scores in the experimental group were dramatically elevated compared with those in the control group (p = 0.03). Conclusion: Vitamin D supplementation improves the typical symptoms of autism spectrum disorder, as indicated by reduced Social Responsiveness Scale and Child Autism Rating Scale scores; thus, it is beneficial for children with autism spectrum disorder.
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참고문헌 (72)
참고문헌 신청
American Psychiatric Association / 2013 / Diagnostic and statistical manual of mental disorders / American Psychiatric Association
Abdallah MW / 2011 / Psychiatric comorbidities in autism spectrum disorders : findings from a Danish historic birth cohort / Eur Child Adolesc Psychiatry 20:599~601
Fombonne E / 2003 / Epidemiological surveys of autism and other pervasive developmental disorders : an update / J Autism Dev Disord 33:365~382
Fombonne E / 2009 / Epidemiology of pervasive developmental disorders / Pediatr Res 65:591~598
Chakrabarti S / 2001 / Pervasive developmental disorders in preschool children / JAMA 285:3093~3099
Abdallah MW / 2011 / Psychiatric comorbidities in autism spectrum disorders : findings from a Danish historic birth cohort / Eur Child Adolesc Psychiatry 20:599~601
Fombonne E / 2003 / Epidemiological surveys of autism and other pervasive developmental disorders : an update / J Autism Dev Disord 33:365~382
Fombonne E / 2009 / Epidemiology of pervasive developmental disorders / Pediatr Res 65:591~598
Chakrabarti S / 2001 / Pervasive developmental disorders in preschool children / JAMA 285:3093~3099
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