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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제12권 제4호
- 발행연도
- 2019.1
- 수록면
- 337 - 347 (11page)
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Neutrophils have traditionally been acknowledged as the first immune cells that are recruited to inflamed tissues during acute inflammation. By contrast, their importance in the context of chronic inflammation has been studied in less depth. Neutrophils can be recruited and are largely present in the nasal mucosa of patients with chronic rhinosinusitis (CRS) both in Asians and in Caucasians. Increased infiltration of neutrophils in patients with CRS has been linked to poor corticosteroid response and disease prognosis. Meanwhile, tissue neutrophils may possess specific phenotypic features distinguishing them from resting blood counterparts and are endowed with particular functions, such as cytokines and chemokines production, thus may contribute to the pathogenesis of CRS. This review aims to summarize our current understanding of the pathophysiologic mechanisms of CRS, with a focus on the roles of neutrophils. We discuss recruitment, function, and regulation of neutrophils in CRS and outline the potential therapeutic strategies targeting neutrophils.
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참고문헌 (105)
참고문헌 신청
Fokkens WJ / 2012 / EPOS 2012 : European position paper on rhinosinusitis and nasal polyps 2012 : a summary for otorhinolaryngologists / Rhinology 50(1):1~12
Schleimer RP / 2017 / Immunopathogenesis of chronic rhinosinusitis and nasal polyposis / Annu Rev Pathol 12(1):331~357
Bachert C / 2015 / Current and future treatment options for adult chronic rhinosinusitis : focus on nasal polyposis / J Allergy Clin Immunol 136(6):1431~1440
Wang X / 2016 / Diversity of TH cytokine profiles in patients with chronic rhinosinusitis : a multicenter study in Europe, Asia, and Oceania / J Allergy Clin Immunol 138(5):1344~1353
Huvenne W / 2009 / Chronic rhinosinusitis with and without nasal polyps: what is the difference? / Curr Allergy Asthma Rep 9(3):213~220
Schleimer RP / 2017 / Immunopathogenesis of chronic rhinosinusitis and nasal polyposis / Annu Rev Pathol 12(1):331~357
Bachert C / 2015 / Current and future treatment options for adult chronic rhinosinusitis : focus on nasal polyposis / J Allergy Clin Immunol 136(6):1431~1440
Wang X / 2016 / Diversity of TH cytokine profiles in patients with chronic rhinosinusitis : a multicenter study in Europe, Asia, and Oceania / J Allergy Clin Immunol 138(5):1344~1353
Huvenne W / 2009 / Chronic rhinosinusitis with and without nasal polyps: what is the difference? / Curr Allergy Asthma Rep 9(3):213~220
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