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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 17 - 17 (1page)
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Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal pathogen Cryptococcus neoformans. Herein, we identified and characterized calcineurin substrates in C. neoformans by employing phosphoproteomic $TiO_2$ enrichment and quantitative mass spectrometry. The identified targets include the zinc finger transcription factor Crz1 and proteins whose functions are linked to P-bodies/stress granules (PBs/SGs) and mRNA translation and decay, such as Pbp1 and Puf4. We show that Crz1 is a bona fide calcineurin substrate, and localization and transcriptional activity of Crz1 are controlled by calcineurin. Several of the calcineurin targets localized to PBs/SGs, including Puf4 and Pbp1, and are required for survival at high temperature and for virulence. Genetic epistasis analysis revealed that Crz1 and the novel targets Lhp1, Puf4, and Pbp1 function in a branched calcineurin pathway that orchestrates stress survival and virulence. These findings propose that calcineurin controls thermal stress and virulence at the transcriptional level via Crz1 and post-transcriptionally by regulating target factors involved in mRNA metabolism.
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Calcineurin Targets Involved in Stress Survival and Virulence in Cryptococcus neoformans
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Calcineurin Targets Involved in Stress Survival and Fungal Virulence
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The Components of Nonsense-mediated mRNA Decay Play Roles in Stress Response in Human Pathogen Cryptococcus neoformans
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Systematic Functional Profiling of Transcription Factor Networks in Cryptococcus neoformans
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Systematic Functional Analysis of Phosphatases in the Fungal Pathogen Cryptococcus neoformans
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Calcineurin Activation by Prion Peptide Induces a NF-kb-driven Proinflammatory Response IN Neuronal Cell
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Extension of O-linked Glycans is Essential for Cell Wall Integrity Signaling and Virulence of the Human Pathogenic Yeast Cryptococcus neoformans
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