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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 95 - 101 (7page)
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Objectives : The aim of this study was to confirm whether or not coral has a preventive effect on development of atopic dermatitis induced by house mite(dermatophagoides pteronyssinus) in NC/Nga mice. Methods : This study was undertaken by using a reliable Atopic dermatitis mouse model demonstrating similar immune response. Lobophytum crassum was administered orally to NC/Nga mouse for 3 weeks. In order to verify the effectiveness of Lobophytum crassum in atopic dermatitis treatment, its role in immune factors were observed in NC/Nga mice. Results : ALT, AST, BUN and creatine levels were all within in the normal ranges in MC-1 200 and 400 (mg/kg) treated groups, indicating no induced toxicity. MC-1 200 and 400 (mg/kg) groups decreased of atopic dermatitis skin manifestation in NC/Nga mouse of MC-1 200 and 400 (mg/kg) groups compared to that of the control group and decreased the ratio of WBC and lymphocyte in blood. Also, MC-1 200 and 400 (mg/kg) groups significant decreased the ratio of CD4+, CD8+, CD11b+/Gr1+, B220/CD23 and CD4/CD25 immune cell ratio in ALN. Finally MC-1 200 and 400 (mg/kg) groups significantly increased the ratio of CD4+, CD8+, B220/CD23 and CD4/CD25 immune cells in DLN. Conclusions : Theses results suggested that Lobophytum crassum has suppressive effects on aberrant and overactive immunological activities in dermatophagoides pteronyssinus-induced dermatitis mice of NC/Nga.
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참고문헌 (32)
참고문헌 신청
Park MH / 2010 / Effect of probiotics is used commercially in the inflammatory response RAW 264.7 macrophages cell
Katayama I / 2014 / Japanese Society of Allergology. Japanese Guideline for Atopic Dermatitis / Allergol Int 63(3):377~398
Duncan CL / 2012 / A review of psychosocial risk factors for pediatric atopy / J Allergy(Cairo) 142(2):3~5
Okada H / 2010 / The 'hygiene hypothesis' for autoimmune and allergic diseases: an update / Clin Exp Immunol 160(1):1~9
심부용 / 2014 / 白鮮皮地膚子複合方의 항아토피피부염 효능에 관한 실험적 연구 / 한의학연구소 논문집 22(2):67~79
Katayama I / 2014 / Japanese Society of Allergology. Japanese Guideline for Atopic Dermatitis / Allergol Int 63(3):377~398
Duncan CL / 2012 / A review of psychosocial risk factors for pediatric atopy / J Allergy(Cairo) 142(2):3~5
Okada H / 2010 / The 'hygiene hypothesis' for autoimmune and allergic diseases: an update / Clin Exp Immunol 160(1):1~9
심부용 / 2014 / 白鮮皮地膚子複合方의 항아토피피부염 효능에 관한 실험적 연구 / 한의학연구소 논문집 22(2):67~79
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