지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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To further access honeybee (Apis mellifera L.) venom (BV) as a cosmetic ingredient and potential external treatment for topical use, we investigated its ability to inhibit tyrosinase activity and melanin biosynthesis on melanogenesis in B16F1 melanoma cells. We found that BV increased the cell viability in B16F1 melanoma cell and BV (0.01~1 ${\mu}g/ml$) inhibited melanin synthesis in with 10 nM ${\alpha}$-melanocyte-stimulating hormone (${\alpha}$-MSH) for 48 h. In addition, we used reverse transcription-polymerase chain reaction and western blotting for me melanogenesis-related genes such as tyrosinase to examine the mechanisms underlying the inhibitory effects of BV on melanogensis. BV inhibited direct tyrosinase activity, which decreased melanin synthesis in ${\alpha}$-MSH stimulated B16F1 melanoma cells. Thease findings suggest that BV induces the downregulation of melanogenesis by inhibiting tyrosinase activation.
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참고문헌 (29)
참고문헌 신청
Urabe, K. / 1998 / Mixed epidermal and dermal hypermelanoses. In The pigmentary System: Physiology and Pathophysiology / Oxford University Press :909
Chang, T. S. / 2009 / An updated review of tyrosinase inhibitors / Int. J. Mol. Sci 10:2440
Imokawa, G / 2004 / Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders / Pigment. Cell Res 17:96
Ando, H. / 2007 / Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase / J. Invest. Dermatol 127:751
Solano, F. / 2006 / Hypopigmenting agents: an updated review on biological, chemical and clinical aspects / Pigment. Cell Res 19:550
Chang, T. S. / 2009 / An updated review of tyrosinase inhibitors / Int. J. Mol. Sci 10:2440
Imokawa, G / 2004 / Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders / Pigment. Cell Res 17:96
Ando, H. / 2007 / Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase / J. Invest. Dermatol 127:751
Solano, F. / 2006 / Hypopigmenting agents: an updated review on biological, chemical and clinical aspects / Pigment. Cell Res 19:550
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