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논문 기본 정보

자료유형
학술저널
저자정보
김선주 (서울대학교) 윤충식 (서울대학교) 함승헌 (서울대학교) 박지훈 (서울대학교) 김송하 (서울대학교) 김유나 (서울대학교) 이지은 (서울대학교) 이상아 (서울대학교) 박동욱 (한국방송통신대학교) 이권섭 (한국산업안전보건공단 산업안전보건연구원) 하권철 (창원대학교)
저널정보
한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제25권 제1호
발행연도
2015.1
수록면
58 - 71 (14page)

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초록· 키워드

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Objectives: The aims of this study were to investigate the classification system of chemical substances in the Occupational Safety and Health Act(OSHA) and Chemical Substances Control Act(CSCA) and to compare several health indices (i.e., Time Weighted Average (TWA), Lethal Dose ($LD_{50}$), and Lethal Concentration ($LC_{50}$) of chemical substances by categories in each law. Methods: The chemicals regulated by each law were classified by the specific categories provided in the respective law; seven categories for OSHA (chemicals with OELs, chemicals prohibited from manufacturing, etc., chemicals requiring approval, chemicals kept below permissible limits, chemicals requiring workplace monitoring, chemicals requiring special management, and chemicals requiring special heath diagnosis) and five categories from the CSCA(poisonous substances, permitted substances, restricted substances, prohibited substances, and substances requiring preparation for accidents). Information on physicochemical properties, health indices including CMR characteristics, $LD_{50}$ and $LD_{50}$ were searched from the homepages of the Korean Occupational and Safety Agency and the National Institute of Environmental Research, etc. Statistical analysis was conducted for comparison between TWA and health index for each category. Results: The number of chemicals based on CAS numbers was different from the numbers of series of chemicals listed in each law because of repeat listings due to different names (e.g., glycol monoethylether vs. 2-ethoxy ethanol) and grouping of different chemicals under the same serial number(i.e., five different benzidine-related chemicals were categorized under one serial number(06-4-13) as prohibited substances under the CSCA). A total of 722 chemicals and 995 chemicals were listed at the OSHA and its sub-regulations and CSCA and its sub-regulations, respectively. Among these, 36.8% based on OSHA chemicals and 26.7% based on CSCA chemicals were regulated simultaneously through both laws. The correlation coefficients between TWA and $LC_{50}$ and between TWA and $LD_{50}$, were 0.641 and 0.506, respectively. The geometric mean values of TWA calculated by each category in both laws have no tendency according to category. The patterns of cumulative graph for TWA, $LD_{50}$, $LC_{50}$ were similar to the chemicals regulated by OHSA and CCSA, but their median values were lower for CCSA regulated chemicals than OSHA regulated chemicals. The GM of carcinogenic chemicals under the OSHA was significantly lower than non-CMR chemicals($2.21mg/m^3$ vs $5.69mg/m^3$, p=0.006), while there was no significant difference in CSCA chemicals($0.85mg/m^3$ vs $1.04mg/m^3$, p=0.448). $LC_{50}$ showed no significant difference between carcinogens, mutagens, reproductive toxic chemicals and non-CMR chemicals in both laws' regulated chemicals, while there was a difference between carcinogens and non-CMR chemicals in $LD_{50}$ of the CSCA. Conclusions: This study found that there was no specific tendency or significant difference in health indicessuch TWA, $LD_{50}$ and $LC_{50}$ in subcategories of chemicals as classified by the Ministry of Labor and Employment and the Ministry of Environment. Considering the background and the purpose of each law, collaboration for harmonization in chemical categorizing and regulation is necessary.
#Chemical substances management #Occupational Safety and Health Act #Chemical Substances Control Act #TWA #acute toxicity #CMR #toxicity

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참고문헌 (16)

참고문헌 신청
Byun HJ / 2013 / Effective risk management system for chemicals in industries / Industrial Engineering & Management Systems 20(2):32~36 google schola 조흠학 / 2011 / 산업안전보건법의 제정에 관한 역사적 의미에 관한 연구 / 법학논고 (37):23~82 dbpia 최상준 / 2013 / 우리나라 산업안전보건법상 특별관리물질 규정에 대한 독일, 영국 및 일본과의 비교법적 고찰 / 한국산업보건학회지 23(2):137~147 google schola Fred A. / 2001 / A history of the international chemical industry / Chemical Heritage Foundation :1~16 google schola Im CH / 2013 / Understanding carcinogenic substances / Korean Industrial Health Association 301:15~20 google schola

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