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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective : The clinical and pathological characteristics of 10 cases of cerebral amyloid angiopathy (CAA)-related cerebral lobar hemorrhage (CLH) that was diagnosed at autopsy were investigated to facilitate the diagnosis of this condition. Methods : The clinical characteristics of 10 cases of CAA-related CLH were retrospectively reviewed, and a neuropathological examination was performed on autopsy samples. Results : The 10 cases included two with a single lobar hemorrhage and eight with multifocal lobar hemorrhages. In all of the cases, the hemorrhage bled into the subarachnoid space. Pathological examinations of the 10 cases revealed microaneurysms in two, double barrel-like changes in four, multifocal arteriolar clusters in five, obliterative onion skin-like intimal changes in four, fibrinoid necrosis of the vessels in seven, neurofibrillary tangles in eight, and senile plaques in five cases. Conclusion : CAA-related CLHs were located primarily in the parietal, temporal, and occipital lobes. These hemorrhages normally consisted of multiple repeated CLHs that frequently bled into the subarachnoid space. CAA-associated microvascular lesions may be the pathological factor underlying CLH.
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참고문헌 (40)
참고문헌 신청
Alexander M. / 2013 / Recurrent craniospinal subarachnoid hemorrhage in cerebral amyloid angiopathy / Ann Indian Acad Neurol 16:97~99
Antonell A. / 2012 / Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer’s disease and severe cerebral amyloid angiopathy / J Alzheimers Dis 28:303~308
Bu G / 2009 / Apolipoprotein E and its receptors in Alzheimer's disease : pathways, pathogenesis and therapy / Nat Rev Neurosci 10:333~344
Chao CP. / 2006 / Cerebral amyloid angiopathy : CT and MR imaging findings / Radiographics 26:1517~1531
Charidimou A. / 2012 / Sporadic cerebral amyloid angiopathy revisited : recent insights into pathophysiology and clinical spectrum / J Neurol Neurosurg Psychiatry 83:124~137
Antonell A. / 2012 / Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer’s disease and severe cerebral amyloid angiopathy / J Alzheimers Dis 28:303~308
Bu G / 2009 / Apolipoprotein E and its receptors in Alzheimer's disease : pathways, pathogenesis and therapy / Nat Rev Neurosci 10:333~344
Chao CP. / 2006 / Cerebral amyloid angiopathy : CT and MR imaging findings / Radiographics 26:1517~1531
Charidimou A. / 2012 / Sporadic cerebral amyloid angiopathy revisited : recent insights into pathophysiology and clinical spectrum / J Neurol Neurosurg Psychiatry 83:124~137
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