지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 296 - 300 (5page)
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초록· 키워드
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We selected Pleurotus ostreatus from among several edible mushrooms because it has high anti-gout xanthine oxidase (XOD) inhibitory activity. The maximal amount of XOD inhibitor was extracted when the Pleurotus ostreatus fruiting body was treated with distilled water at $40^{\circ}C$ for 48 hr. The XOD inhibitor thus obtained was purified by Sephadex G-50 gel permeation chromatography, ultrafiltration, $C_{18}$ solid phase extraction chromatography and reverse-phase high-performance liquid chromatography with 3% of solid yield, and its XOD inhibitory activity was 0.9 mg/mL of $IC_{50}$. The purified XOD inhibitor was a tripeptide with the amino acid sequence phenylalanine-cysteine-histidine and a molecular weight of 441.3 Da. The XOD inhibitor-containing ultrafiltrates from Pleurotus ostreatus demonstrated dose-dependent anti-gout effects in a Sprague-Dawley rat model of potassium oxonate-induced gout, as shown by decreased serum urated levels at doses of 500 and 1,000 mg/kg, although the effect was not as great as that achieved with the commercial anti-gout agent, allopurinol when administered at a dose of 50 mg/kg.
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참고문헌 (19)
참고문헌 신청
Jang JH / 2011 / Characterization of a new antihypertensive angiotensin I-converting enzyme inhibitory peptide from Pleurotus cornucopiae / Food Chem 127:412~418
Lee DH / 2004 / Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum / Peptides 25:621~627
Shen HS / 2012 / Biodegrading wheat bran with Agaricus blazei and its effects on intestinal development identified with mice / J Integr Agric 11:456~464
Gern RM / 2008 / Alternative medium for production of Pleurotus ostreatus biomass and potential antitumor polysaccharides / Bioresour Technol 99:76~82
Wang H / 2000 / A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus / Biochem Biophys Res Commun 275:810~816
Lee DH / 2004 / Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum / Peptides 25:621~627
Shen HS / 2012 / Biodegrading wheat bran with Agaricus blazei and its effects on intestinal development identified with mice / J Integr Agric 11:456~464
Gern RM / 2008 / Alternative medium for production of Pleurotus ostreatus biomass and potential antitumor polysaccharides / Bioresour Technol 99:76~82
Wang H / 2000 / A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus / Biochem Biophys Res Commun 275:810~816
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