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논문 기본 정보

자료유형
학술저널
저자정보
Jo, Mi-Jeong (College of Oriental Medicine, BK21 Team, Daegu Haany University) Chu, Yan-Hui (Department of Biochemistry, Key Laboratory of Heilongjiang Province, Mudanjiang Medical University) Back, Young-Doo (College of Oriental Medicine, Daegu Haany University) Lee, Byung-Wook (College of Oriental Medicine, Daegu Haany University) Shin, Soon-Shik (College of Oriental Medicine, Dongeui University) Kwon, Young-Kyu (College of Oriental Medicine, BK21 Team, Daegu Haany University) Kim, Sang-Chan (College of Oriental Medicine, BK21 Team, Daegu Haany University)
저널정보
대한동의생리학회 동의생리병리학회지 동의생리병리학회지 제22권 제4호
발행연도
2008.1
수록면
907 - 913 (7page)

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Taraxci Herba (TH; Pogongyoung in Korean) has been used in traditional oriental medicine for the treatment of various ailments. The biological activity of this plant is not yet evaluated systematically. This study was conducted to evaluate the inhibitory effects of TH on the production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated Raw264.7 cells. The aim of the present work is to investigate a potential anti-inflammatory activity of TH. The Raw264.7 cells were cultured in DMEM medium for 24 h. After serum starvation for 12 h, the cells were treated with TH for 1 h, followed by stimulating NO production with LPS ($2{\mu}g/ml$). As result of this study, TH inhibited the levels of NO, PGE2, $TNF-{\alpha}$, IL-6 and $IL-1{\beta}$, and the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activated by LPS. These inhibitory effects were mediated though the inhibition of phosphorylation of inhibitory kappa B ($I{\kappa}B$). These findings showed that TH could have some anti-inflammatory effects.

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