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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 79 - 87 (9page)
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Objectives : This study aimed to investigate the protective effects of an herbal mixture of Atractylodes macrocephala and Taraxacum spp. (ATC) on ulcerative colitis. We have previously screened traditional medicinal herbs to discover the effective candidate by the animal model. A. macrocephala and T. spp were identified as one of the effective herbs in the screening process. Methods : Experimental colitis was induced in male Balb/c mice by administering drinking water containing dextran sulfate sodium, which mimics the clinical and histological features of ulcerative colitis in human. ATC at doses of 30, 100 or 300 mg/kg were orally administered to mice twice per day for 10 consecutive days. To evaluate the damage from experimentla ulcerative colitis, body weight, colon length, disease activity index, myeloperoxidase and histological changes were measured and analyzed. Results : The administration of dextran sulfate sodium with drinking water resulted in markedly reduced colon length, severe body weight loss, increased levels of myeloperoxidase activity and histological damages in mice. ATC treatment significantly ameliorated the colon shortening, histological damage, body weight loss and disease activity index score in a dose-dependent manner. ATC also attenuated the colonic myeloperoxidase activity which reflects the severity and extent of inflammatory damage of colon. Conclusions : ATC exerts protective effects against inflammatory colonic structural damage induced by epithelial barrier integrity impairment. ATC also inhibits weight loss and related symptoms of UC which can be considered as the functional recovery of colon.
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참고문헌 (39)
참고문헌 신청
Head KA / 2003 / Inflammatory bowel disease Part 1: ulcerative colitis--pathophysiology and conventional and alternative treatment options / Alternative medicine review : a journal of clinical therapeutic 8:247~283
Loftus EV,Jr / 2004 / Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences / Gastroenterology 126:1504~1517
Campieri M / 2001 / Bacteria as the cause of ulcerative colitis / Gut 48:132~135
Sartor RB / 2006 / Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis / Nature clinical practice Gastroenterology & hepatology 3:390~407
Fournier BM / 2012 / The role of neutrophils during intestinal inflammation 5:354~366
Loftus EV,Jr / 2004 / Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences / Gastroenterology 126:1504~1517
Campieri M / 2001 / Bacteria as the cause of ulcerative colitis / Gut 48:132~135
Sartor RB / 2006 / Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis / Nature clinical practice Gastroenterology & hepatology 3:390~407
Fournier BM / 2012 / The role of neutrophils during intestinal inflammation 5:354~366
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