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논문 기본 정보

자료유형
학술저널
저자정보
Park, In-Hye (Division of Applied Biology &) Chung, Shin-Kyo (Chemistry) Lee, Kyung-Bok (Department of Food Science &) Yoo, Yung-Choon (Technology, College of Agriculture and Life Sciences, Kyungpook National University) Kim, Suk-Kyung (College of Medicine, Konyang University) Kim, Geum-Soog (College of Medicine, Konyang University) Song, Kyung-Sik (Department of Food Science &)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제27권 제6호
발행연도
2004.1
수록면
615 - 618 (4page)

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In the course of screening for reactive oxygen species scavengers from natural products, an antioxidant was isolated from the mycelial culture broth of Phellinus linteus and identified as hispidin. The hispidin content was reached its maximum level at 12 days after onset of inoculation. About 2.5 mg/mL of hispidin was produced by P linteus in a yeast-malt medium (pH 5.8, $25^{\circ}C$). Hispidin inhibited 22.6 and 56.8% of the super oxide anion radical, 79.4 and 95.3% of the hydroxyl radical, and 28.1 and 85.5% of the DPPH radical at 0.1 and 1.0 mM, respectively. The positive control ${\alpha}-tocopherol$ scavenged 25.6 and 60.3%, 74.6 and 96.3%, and 32.7 and 77.5% of each radical, respectively, at the same concentrations. However, hispidin showed no significant activity on the hydrogen peroxide radical.

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