지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.11
- 수록면
- 823 - 832 (10page)
이용수
초록· 키워드
오류제보하기
Background: The formation of a nanotube layer on a titanium nanotube (N-Ti) plate facilitates an active reaction between bone cells and the material surface via efficient delivery of the surface materials of the dental implant into the tissues. Studies have reported that Korean Red Ginseng extracts (KRGEs) are involved in a variety of pharmacological activities: we investigated whether implantation with a KRGE-loaded N-Ti miniimplant affects osteogenesis and osseointegration.
Methods: KRGE-loaded nanotubes were constructed by fabrication on pure Ti via anodization, and MC3T3-E1 cells were cultured on the N-Ti. N-Ti implants were subsequently placed on a rat"s edentulous mandibular site. New bone formation and bone mineral density were measured to analyze osteogenesis and osseointegration.
Results: KRGE-loaded N-Ti significantly increased the proliferation and differentiation of MC3T3-E1 cells compared with cells on pure Ti without any KRGE loading. After 1-4 weeks, the periimplant tissue in the edentulous mandibular of the healed rat showed a remarkable increase in new bone formation and bone mineral density. In addition, high levels of the bone morphogenesis protein-2 and bone morphogenesis protein-7, besides collagen, were expressed in the periimplant tissues.
Conclusion: Our findings suggest that KRGE-induced osteogenesis and osseointegration around the miniimplant may facilitate the clinical application of dental implants.
Methods: KRGE-loaded nanotubes were constructed by fabrication on pure Ti via anodization, and MC3T3-E1 cells were cultured on the N-Ti. N-Ti implants were subsequently placed on a rat"s edentulous mandibular site. New bone formation and bone mineral density were measured to analyze osteogenesis and osseointegration.
Results: KRGE-loaded N-Ti significantly increased the proliferation and differentiation of MC3T3-E1 cells compared with cells on pure Ti without any KRGE loading. After 1-4 weeks, the periimplant tissue in the edentulous mandibular of the healed rat showed a remarkable increase in new bone formation and bone mineral density. In addition, high levels of the bone morphogenesis protein-2 and bone morphogenesis protein-7, besides collagen, were expressed in the periimplant tissues.
Conclusion: Our findings suggest that KRGE-induced osteogenesis and osseointegration around the miniimplant may facilitate the clinical application of dental implants.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (23)
참고문헌 신청
Oshida Y / 2010 / Dental implant systems / Int J Mol Sci 11:1580~1678
Adell R / 1985 / Tissue integrated prostheses in clinical dentistry / Int Dent J 35:259~265
Miao X / 2017 / The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces : a systematic study / Int J Nanomedicine 12:1415~1430
Park J / 2007 / Nanosize and vitality : TiO2nanotube diameter directs cell fate / Nano Lett 7:1686~1691
Das K / 2009 / TiO2 nanotubes on Ti : influence of nanoscale morphology on bone cell-materials interaction / J Biomed Mater Res A 90:225~237
Adell R / 1985 / Tissue integrated prostheses in clinical dentistry / Int Dent J 35:259~265
Miao X / 2017 / The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces : a systematic study / Int J Nanomedicine 12:1415~1430
Park J / 2007 / Nanosize and vitality : TiO2nanotube diameter directs cell fate / Nano Lett 7:1686~1691
Das K / 2009 / TiO2 nanotubes on Ti : influence of nanoscale morphology on bone cell-materials interaction / J Biomed Mater Res A 90:225~237
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