지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 471 - 480 (10page)
- DOI
- 10.7783/KJMCS.2020.28.6.471
이용수
초록· 키워드
오류제보하기
Background: The roots of Cirsium japonicum var. ussuriense (RCJ) have been used as traditional medicine in Korea for hematuria and hematemesis. These extracts exert anti-oxidative and anti-inflammatory effects by scavenging for free radical and regulating the inflammatory response. However, the effect of RCJ on rheumatoid arthritis (RA) has not been elucidated. Thus, we evaluated the water extract of RCJ (WRCJ) using type II collagen-induced RA models.
Methods and Results: RA was induced by immunization with type II collagen. All experimental materials were orally administered daily for three weeks. The positive control group was administered with 0.2 ㎎/㎏ methotrexate (n = 7), while the experimental group was administered with WRCJ (100 or 500 ㎎/㎏, n = 7). Serum levels of TNF-alpha, Interleukin 6 (IL-6), and type II collagen IgG (CII) were measured using ELISA. Administration of 500 ㎎/㎏ WRCJ decreased the levels of TNF-alpha, IL-6, and CII. Moreover, WRCJ treatment diminished swelling of hind legs and infiltration of inflammatory cells in RA models’ synovial membrane.
Conclusions: These results indicate that WRCJ could improve RA, reduce inflammatory indicators and synovial inflammation. However, further experiments are required to determine how WRCJ can influence the signal transduction pathway in RA.
Methods and Results: RA was induced by immunization with type II collagen. All experimental materials were orally administered daily for three weeks. The positive control group was administered with 0.2 ㎎/㎏ methotrexate (n = 7), while the experimental group was administered with WRCJ (100 or 500 ㎎/㎏, n = 7). Serum levels of TNF-alpha, Interleukin 6 (IL-6), and type II collagen IgG (CII) were measured using ELISA. Administration of 500 ㎎/㎏ WRCJ decreased the levels of TNF-alpha, IL-6, and CII. Moreover, WRCJ treatment diminished swelling of hind legs and infiltration of inflammatory cells in RA models’ synovial membrane.
Conclusions: These results indicate that WRCJ could improve RA, reduce inflammatory indicators and synovial inflammation. However, further experiments are required to determine how WRCJ can influence the signal transduction pathway in RA.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (49)
참고문헌 신청
Adouani I / 2013 / Identification and determination of related substances in diosmin bulk drug and pharmaceutical formulations by HPLC and HPLC–MS / Chromatographia 76:499~508
Bedoya ME / 2015 / Spleen and liver enlargement in a patient with rheumatoid arthritis / Reumatología Clinica 11:227~231
Bradley JR / 2008 / TNF-mediated inflammatory disease / Journal of Pathology 214:149~160
Brown PM / 2016 / Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers / Nature Reviews Rheumatology 12:731~742
Burmester GR / 1983 / Identification of three major synovial lining cell populations by monoclonal antibodies directed to Ia antigens and antigens associated with monocytes/macrophages and fibroblasts / Scandinavian Journal of Immunology 17:69~82
Bedoya ME / 2015 / Spleen and liver enlargement in a patient with rheumatoid arthritis / Reumatología Clinica 11:227~231
Bradley JR / 2008 / TNF-mediated inflammatory disease / Journal of Pathology 214:149~160
Brown PM / 2016 / Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers / Nature Reviews Rheumatology 12:731~742
Burmester GR / 1983 / Identification of three major synovial lining cell populations by monoclonal antibodies directed to Ia antigens and antigens associated with monocytes/macrophages and fibroblasts / Scandinavian Journal of Immunology 17:69~82
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Inflammatory Protective and Improvement Effects of Ethanolic Extracts from Cirsium japonicum var. ussuriense in LPSstimulated RAW264.7 cells
한국식품영양과학회 학술대회발표집
2015 .08
-
Impacts of Different Amounts of N, P, and K Fertilizer Applications on Growth of Cirsium japonicum var. ussuriense Related to Soil Properties
한국토양비료학회지
2018 .08
-
In Vitro and In Vivo Antiviral Activities of Cirsium japonicum var. ussuriense leaves against Viral Hemorrhagic Septicemia Virus
한국수산과학회 양식분과 학술대회
2015 .10
-
Protective Effects of Cirsium Japonicum var. maackii on the Arthritis and the Qualitative Analyses of Water Extracts
한국약용작물학회 학술대회논문집
2018 .05
-
민들레 뿌리 물 추출물의 류마티스 관절염 동물 모델에 대한 개선 효과
한국약용작물학회지
2019 .02
-
Anti-Inflammation And Hepatoprotective Effects of Leaf Extracts Composed of Cirsium japonicum var. ussuriense and Silybum marianum L. Gaertn
한국약용작물학회 학술대회논문집
2016 .05
-
Neuroprotective Effects of Flower from Cirsium japonicum var. maackii against H₂O₂-induced C6 Glial Cells
한국식품영양과학회 학술대회발표집
2024 .10
-
Free radical scavenging activity of Cirsium japonicum var. maackii flower
Korean Journal of Agricultural Science
2023 .03
-
Protective effects of Cirsium japonicum var. maackii against amyloid beta-induced neurotoxicity in C6 glial cells
Korean Journal of Agricultural Science
2019 .06
-
Effect of Extraction Variable on Flavonoid Contents of Cirsium japonicum var. Maackii and Analysis by HPLC
한국원예학회 학술발표요지
2017 .05
-
Cirsium japonicum var. maackii Extract Suppress Vascular Adhesion Factor Expression in TNF-α-treated Human Vascular Endothelial Cells by Inhibiting NF-κB Activation
한국식품영양과학회 학술대회발표집
2022 .10
-
Protective Effects against Cognitive Impairment by Cirsium japonicum var. maackii Flower on the Role of Gut-Brain Axis
한국식품영양과학회 학술대회발표집
2023 .10
-
약용식물(오크라, 엉컹퀴, 엄나무, 줄풀) 유래 페놀성 물질의 항산화 활성
경북대농학지
2015 .01
-
좁은잎 엉겅퀴 추출물의 산화방지 활성 및 산화적 스트레스에 대한 PC12 세포 보호효과
한국식품과학회지
2016 .04
-
Immunostimulatory Activity of Cirsium japonicum var. maackii Derived-Natural Substances in RAW 264.7 Mouse Macrophages
한국식품영양과학회 학술대회발표집
2023 .10
-
Immune-enhancing effects of Pediococcus pentosaceus-Cirsium japonicum var. maackii fermentation
한국식품영양과학회 학술대회발표집
2022 .10
-
Development of Proper Seed-Gathering Technology for Production of High Quality Seed in Cirsium japonicum var.
한국약용작물학회 학술대회논문집
2020 .10
-
Development of Proper Seed-gathering Technology for Production of High Quality Seed in Cirsium japonicum var.
한국약용작물학회 학술대회논문집
2019 .10
-
Immunomodulatory Effects of Cirsium japonicum var. maackii-derived Flavone Components on Natural Killer Cell Activity and Apoptotic Pathways
한국식품영양과학회 학술대회발표집
2024 .10
-
Anti-Inflammatory and Anti-Pruritic Effect of Peucedanum japonicum Root Extract in in vitro
한국식품영양과학회 학술대회발표집
2022 .10
이 논문의 저자 정보
이 논문과 함께 이용한 논문
호모루덴스의 유희적 특성을 적용한 공동업무공간 계획에 관한 연구
이준해
,
김정기
한국실내디자인학회 학술대회논문집
2014
.11
민들레 뿌리 물 추출물의 류마티스 관절염 동물 모델에 대한 개선 효과
노종현
,
이현주
,
장지훈
외 7명
한국약용작물학회지
2019
.02
4차 산업혁명 시대 유아 핵심역량과 유아교육 방향
오은순
,
김윤희
디지털콘텐츠학회논문지
2019
.05
고구마껍질을 주원료로 한 식물혼합물의 면역증강 및 항암효과
정인선
,
강경순
,
김은혜
외 2명
한국식품영양과학회지
2020
.12
피부 재생을 위한 줄기세포 유래 세포 외 소포의 응용
박주현
BT NEWS
2020
.07
최근 본 자료
댓글(0)
0