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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Dong Hyeok Kim (Catholic University of Pusan) Hyunwoo Jin (Catholic University of Pusan) Kyung Eun Lee (Catholic University of Pusan)
저널정보
대한의생명과학회 대한의생명과학회지 대한의생명과학회지 제27권 제1호
발행연도
2021.3
수록면
28 - 34 (7page)

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초록· 키워드

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The main cause of cervical cancer is a persistent infection with high-risk human papillomavirus (HR-HPV). Cervical cancer is reported as a preventable cancer in more than 80% of cases with early diagnosis and appropriate treatment. Papanicolaou test (Pap test) has been a global strategy to prevent cervical cancer, and recently, HPV test has been reported to be effective against cervical cancer and precancerous lesions. However, pelvic examinations give patients anxiety, discomfort, pain, distress, and psychological stress. HPV test via a urine sample caused less physical and psychological stress and more advantage than the Pap test. Therefore, it is necessary to study the usefulness of the HPV test for easy-to-collect urine samples. A total of 220 samples were collected from a pair of cervical and urine samples from 110 women and only 108 pairs of samples out of 110 were used because 2 cases were not amplified by β-globin. Among 108 pairs of cervical and urine samples, the prevalence of HPV was 37.0% (40/108) in cervical samples, 34.3% (37/108) in urine samples and HR-HPV was 22.2% (24/108) in cervical samples, 18.5% (20/108) in urine samples. In this study, urine samples showed a lower positive rate of HPV than cervical samples. There were many variables that could affect the condition of the urine sample. However, the HR-HPV agreement rate of the cervix and urine samples was 94.44% and the Kappa value was 0.823, which was "almost perfect". Through these results showed the significance of cervical cancer screening using a urine sample. Cervical screening is crucial, as cervical cancer can be prevented in more than 90% of cases. Urine samples collected by non-invasive methods may have the potential advantage of increasing acceptance of cervical cancer screening. Therefore, it is necessary to develop a new cervical cancer screening strategy using urine samples through further study based on the results of this study.
#Cervical cancer #Human papillomavirus #HPV DNA test #Urine

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (24)

참고문헌 신청
Aitken CA / 2019 / Introduction of primary screening using high-risk HPV DNA detection in the Dutch cervical cancer screening programme : a populationbased cohort study / BMC Med 17:228 google schola Asciutto KC / 2018 / Self-sampling with HPV mRNA analyses from vagina and urine compared with cervical samples / J Clin Virol 101:69~73 google schola Bernal S / 2014 / Comparison of urine and cervical samples for detecting human papillomavirus(HPV)with the Cobas 4800 HPV test / J Clin Virol 61:548~552 google schola Cho HW / 2019 / Comparison of urine, self-collected vaginal swab, and cervical swab samples for detecting human papillomavirus(HPV)with Roche Cobas HPV, Anyplex II HPV, and RealTime HR-S HPV assay / J Virol Methods 269:77~82 google schola Colpani V / 2020 / Prevalence of human papillomavirus(HPV)in Brazil : A systematic review and meta-analysis / PLoS One 15:e0229154 google schola

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