지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 89 - 98 (10page)
- DOI
- 10.7783/KJMCS.2021.29.2.89
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초록· 키워드
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Background: Snow lotus [Saussurea involucrata (Kar. & Kir.) Sch. Bip.] is used in Chinese herbal medicine because of its antioxidant and anti-inflammatory effects. The mechanism of its anti-inflammatory effect on allergic response is unknown.
Methods and Results: We evaluated the effect of the aqueous extract of S. involucrata flowers on the allergic inflammatory response in dinitrophenyl-immunoglobulin E (DNP-IgE)-activated RBL-2H3 cells. Cell viability and β-hexosaminidase release from the activated RBL-2H3 cells were evaluated. The levels of proinflammatory molecules including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-4, IL-10, IL-1β, and prostaglandin E2 in RBL-2H3 cells treated with 5% and 10% S. involucrata extract. Treatment with S. involucrata extract significantly suppressed the phosphorylation of protein kinase B (AKT), p38, c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK)1/2, and mitogen-activiated protein kinase (MEK) in a dose-dependent manner. S. involucrata extract also inhibited the Fc epsilon receptor 1 signaling pathway involving phosphorylation of Lyn, Syk, and phosphoinositide 3-kinase (PI3K), which is associated with the PI3K-AKT-ERK pathway and cytokine expression. A major mechanism of action of S. involucrata extract was to reduce the extent of the DNP-IgE-induced cytoskeletal change from globular to filamentous actin in RBL-2H3 cells.
Conclusions: S. involucrata extract mediates its antiallergic effect by suppressing inflammation. The findings will be valuable in the development of S. involucrata extract as a phytomedicine with minimal side effects for allergic diseases.
Methods and Results: We evaluated the effect of the aqueous extract of S. involucrata flowers on the allergic inflammatory response in dinitrophenyl-immunoglobulin E (DNP-IgE)-activated RBL-2H3 cells. Cell viability and β-hexosaminidase release from the activated RBL-2H3 cells were evaluated. The levels of proinflammatory molecules including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-4, IL-10, IL-1β, and prostaglandin E2 in RBL-2H3 cells treated with 5% and 10% S. involucrata extract. Treatment with S. involucrata extract significantly suppressed the phosphorylation of protein kinase B (AKT), p38, c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK)1/2, and mitogen-activiated protein kinase (MEK) in a dose-dependent manner. S. involucrata extract also inhibited the Fc epsilon receptor 1 signaling pathway involving phosphorylation of Lyn, Syk, and phosphoinositide 3-kinase (PI3K), which is associated with the PI3K-AKT-ERK pathway and cytokine expression. A major mechanism of action of S. involucrata extract was to reduce the extent of the DNP-IgE-induced cytoskeletal change from globular to filamentous actin in RBL-2H3 cells.
Conclusions: S. involucrata extract mediates its antiallergic effect by suppressing inflammation. The findings will be valuable in the development of S. involucrata extract as a phytomedicine with minimal side effects for allergic diseases.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (32)
참고문헌 신청
Baird B / 2020 / How does the actin cytoskeleton regulate distribution and diffusion of membrane components? / Biophysical Journal 118:15a
Thi Tho Bui / 2017 / Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release / Anatomy and Cell Biology 50(2):124~134
Bundgaard L / 2018 / Evaluation of systemic and local inflammatory parameters and manifestations of pain in an equine experimental wound model / Journal of Equine Veterinary Science 68:81~87
Draberova L / 2019 / Cytoskeletal protein 4.1R is a positive regulator of the fcεri signaling and chemotaxis in mast cells / Frontiers in Immunology 10:3068
Kun Guo / 2020 / Hesperidin Protects Against Intestinal Inflammation by Restoring Intestinal Barrier Function and Up‐Regulating Treg Cells / Molecular Nutrition & Food Research 64(10):1970058
Thi Tho Bui / 2017 / Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release / Anatomy and Cell Biology 50(2):124~134
Bundgaard L / 2018 / Evaluation of systemic and local inflammatory parameters and manifestations of pain in an equine experimental wound model / Journal of Equine Veterinary Science 68:81~87
Draberova L / 2019 / Cytoskeletal protein 4.1R is a positive regulator of the fcεri signaling and chemotaxis in mast cells / Frontiers in Immunology 10:3068
Kun Guo / 2020 / Hesperidin Protects Against Intestinal Inflammation by Restoring Intestinal Barrier Function and Up‐Regulating Treg Cells / Molecular Nutrition & Food Research 64(10):1970058
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