지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 187 - 187 (1page)
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Purpose
The Oncotype DX 21-gene recurrence score (21-gene RS), which is most widely used multi-gene test to predict a prognosis and determine adjuvant chemotherapy, is known to be associated with endocrine resistance in ER+/HER2- breast cancer. Several lines of evidence support that TP53 mutation is associated with endocrine resistance in ER+ breast cancer. To date, there is no report regarding the relationship between TP53 mutation and 21-gene recurrence score. We investigated whether TP53 mutation is linked with 21-gene RS in patients with ER+/HER2- breast cancer. We further evaluated molecular characteristics of ER+/HER2- breast cancer according to TP53 mutation using the TCGA.
Method
We identified 141 patients who underwent TP53 gene sequencing and Oncotype DX test between August 2011 and March 2020 at a single institute. Mutational analysis of the TP53 gene was carried out using TP53 Sanger direct sequencing or targeted NGS with the Oncomine™ comprehensive panel (Thermo Fisher Scientific, Waltham, MA, USA). Clinicopathological variables were compared. Multivariable binary logistic regression analysis was performed to identify predictive factors for high 21-gene RS (≥26). In addition, we analyzed 356 patients with stage 1/2, ER+/PR+/HER2- breast cancer from TCGA database.
Resul ... 전체 초록 보기
The Oncotype DX 21-gene recurrence score (21-gene RS), which is most widely used multi-gene test to predict a prognosis and determine adjuvant chemotherapy, is known to be associated with endocrine resistance in ER+/HER2- breast cancer. Several lines of evidence support that TP53 mutation is associated with endocrine resistance in ER+ breast cancer. To date, there is no report regarding the relationship between TP53 mutation and 21-gene recurrence score. We investigated whether TP53 mutation is linked with 21-gene RS in patients with ER+/HER2- breast cancer. We further evaluated molecular characteristics of ER+/HER2- breast cancer according to TP53 mutation using the TCGA.
Method
We identified 141 patients who underwent TP53 gene sequencing and Oncotype DX test between August 2011 and March 2020 at a single institute. Mutational analysis of the TP53 gene was carried out using TP53 Sanger direct sequencing or targeted NGS with the Oncomine™ comprehensive panel (Thermo Fisher Scientific, Waltham, MA, USA). Clinicopathological variables were compared. Multivariable binary logistic regression analysis was performed to identify predictive factors for high 21-gene RS (≥26). In addition, we analyzed 356 patients with stage 1/2, ER+/PR+/HER2- breast cancer from TCGA database.
Resul ... 전체 초록 보기
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