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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 230 - 236 (7page)
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Background
This study investigated the optimal timing to initiate assessing the response to initial therapy during early postoperative period in patients with differentiated thyroid carcinoma (DTC) using dynamic risk stratification (DRS).
Methods
This historical cohort study included 510 patients with DTC who underwent a total thyroidectomy followed by radioactive iodine (RAI) remnant ablation. DRS for these patients was categorized into subgroups according to the time into the follow-up period at which the response to initial therapy was assessed. The ability of each DRS subgroup to predict the long-term structural recurrence of cancer, was compared using proportion of variance explained (PVE) from logistic regression models.
Results
The median follow-up period was 108 months. Structural recurrence occurred in 7.6% of the patients (n=39/510). The PVE for long-term structural recurrence was higher among DRS subgroups (28.8–34.19%) compared to the Tumor-Node-Metastasis staging system (both 7th and 8th editions; 4.01% and 6.13%, respectively) and the American Thyroid Association initial risk estimate (4.59%). Among the DRS subgroups, DRS assessed between two and three years after the initial surgery was associated with the highest PVE (34.19%).
Conclusions
The first assessment of DRS optimally predicts long-term structural recurrence in patients with DTC who underwent a total thyroidectomy and subsequent RAI remnant ablation at that 2-3 postoperative year period.
This study investigated the optimal timing to initiate assessing the response to initial therapy during early postoperative period in patients with differentiated thyroid carcinoma (DTC) using dynamic risk stratification (DRS).
Methods
This historical cohort study included 510 patients with DTC who underwent a total thyroidectomy followed by radioactive iodine (RAI) remnant ablation. DRS for these patients was categorized into subgroups according to the time into the follow-up period at which the response to initial therapy was assessed. The ability of each DRS subgroup to predict the long-term structural recurrence of cancer, was compared using proportion of variance explained (PVE) from logistic regression models.
Results
The median follow-up period was 108 months. Structural recurrence occurred in 7.6% of the patients (n=39/510). The PVE for long-term structural recurrence was higher among DRS subgroups (28.8–34.19%) compared to the Tumor-Node-Metastasis staging system (both 7th and 8th editions; 4.01% and 6.13%, respectively) and the American Thyroid Association initial risk estimate (4.59%). Among the DRS subgroups, DRS assessed between two and three years after the initial surgery was associated with the highest PVE (34.19%).
Conclusions
The first assessment of DRS optimally predicts long-term structural recurrence in patients with DTC who underwent a total thyroidectomy and subsequent RAI remnant ablation at that 2-3 postoperative year period.
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