지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 99 - 117 (19page)
- DOI
- 10.7841/ksbbj.2021.36.2.99
이용수
초록· 키워드
오류제보하기
Chemical anticancer drugs that have been used for a long time for the treatment of cancer have high anticancer effects and many side effects. The side effects of anticancer drugs have also affected normal cells because they induce the death of cancer cells by inhibiting or blocking essential mechanisms for cell survival. Recently, inhibitory drugs that inhibit specific mechanisms of cancer cells are receiving a lot of attention as anticancer drugs. Inhibitory drugs have less effect on normal cells by inhibiting the activity of target proteins that are overexpressed in cancer cells. Representative anticancer inhibitors among many inhibitory drugs are mTOR inhibitors, topoisomerase inhibitors, heat shock protein 90 (HSP90) inhibitors and tyrosine kinase inhibitors. For each of these inhibitor family, new candidate inhibitor drugs are continuously being developed and clinical trials are underway. In this review, we will examine the drug mechanism of each inhibitor drug, and describe the approved drugs and drugs in clinical trials.
목차
Abstract
1. INTRODUCTION
2. TOPOISOMERASE INHIBITOR
3. HEAT SHOCK PROTEIN 90(HSP90) INHIBITOR
4. MTOR(MAMMALIAN TARGET OF REPAPMYCIN) INHIBITOR
5. TYROSINE KINASE INHIBITOR
6. CONCLUSION
REFERENCES
참고문헌 (104)
참고문헌 신청
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Weaver, K. E. / 2010 / Mental and physical health-related quality of life among U.S. cancer survivors: population estimates from the 2010 National Health Interview Survey / Cancer Epidemiol Biomarkers Prev 21:2108~2117
Chabner, B. A. / 2005 / Timeline : Chemotherapy and the war on cancer / Nat Rev Cancer 5:65~72
Xu, Z. / 2019 / Novel HER2-Targeting Antibody-Drug Conjugates of Trastuzumab Beyond T-DM1 in Breast Cancer : Trastuzumab Deruxtecan(DS-8201a)and(Vic-)Trastuzumab Duocarmazine(SYD985) / Eur J Med Chem 183:111682
Gellert, M. / 1976 / DNA gyrase : an enzyme that introduces superhelical turns into DNA / Proc Natl Acad Sci U S A 73:3872~3876
Weaver, K. E. / 2010 / Mental and physical health-related quality of life among U.S. cancer survivors: population estimates from the 2010 National Health Interview Survey / Cancer Epidemiol Biomarkers Prev 21:2108~2117
Chabner, B. A. / 2005 / Timeline : Chemotherapy and the war on cancer / Nat Rev Cancer 5:65~72
Xu, Z. / 2019 / Novel HER2-Targeting Antibody-Drug Conjugates of Trastuzumab Beyond T-DM1 in Breast Cancer : Trastuzumab Deruxtecan(DS-8201a)and(Vic-)Trastuzumab Duocarmazine(SYD985) / Eur J Med Chem 183:111682
Gellert, M. / 1976 / DNA gyrase : an enzyme that introduces superhelical turns into DNA / Proc Natl Acad Sci U S A 73:3872~3876
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UCI(KEPA) : I410-ECN-0101-2021-470-001849476