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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 173 - 173 (1page)
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The shape of nanoparticles were related to catalytic performance, which can lead to different therapeutic effect. In this study, we examined and compared outcomes in in vivo mild traumatic brain injury (mTBI) mouse model between Ceria NSs (CeO2 NSs; ceria nanospheres) and Ceria NRs (CeO2 NRs; ceria nanorods). In vivo mTBI was established in a mouse model of open-head injury via stereotaxic impactor. Outcomes including neuroprotective effect, cognitive function, and cerebral edema were analyzed after retro-orbital (RO) injection of a dose of 11.6 mM of CeO2 NSs and CeO2 NRs. Compared with nontreated control group, ceria nanoparticles group exhibited significant reduction of FJB- and TUNEL-positive cells, and restoration of mRNA expression of SOD1 and SOD2, and reduced of COX-2 expression. Comparing the two cerium oxide nanoparticles, less stable and high-energy (100) and (11 ... 전체 초록 보기
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