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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 1 - 12 (12page)
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Hyperinflammation and cytokine storm has been noted as a poor prognostic factor in patients with severe pneumonia related to coronavirus disease 2019 (COVID-19). In COVID-19, pathogenic myeloid cell overactivation is found to be a vital mediator of damage to tissues, hypercoagulability, and the cytokine storm. These cytokines unselectively infiltrate various tissues, such as the lungs and heart, and nervous system. This cytokine storm can hence cause multi-organ dysfunction and life-threatening complications. Mavrilimumab is a monoclonal antibody (mAb) that may be helpful in some cases with COVID-19. During an inflammation, Granulocyte-macrophage colony-stimulating factor (GM-CSF) release is crucial to driving both innate and adaptive immune responses. The GM-CSF immune response is triggered when an antigen attaches to the host cell and induces the signaling pathway. Mavrilimumab antagonizes the action of GM-CSF and decreases the hyperinflammation associated with pneumonia in COVID-19, therefore strengthening the rationale that mavrilimumab when added to the standard protocol of treatment could improve the clinical outcomes in COVID-19 patients, specifically those patients with pneumonia. With this review paper, we aim to demonstrate the inhibitory effect of mavrilimumab on cytokine storms in patients with COVID-19 by reviewing published clinical trials and emphasize the importance of extensive future trials.
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참고문헌 (33)
참고문헌 신청
Singh Tomar PP / 2020 / SARS-CoV-2 E protein is a potential ion channel that can be inhibited by Gliclazide and Memantine / Biochem Biophys Res Commun 530:10~14
Hoffmann M / 2020 / SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor / Cell 181:271~280
Bonaventura A / 2020 / Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies / Front Immunol 1:1625
Trapnell BC / 2009 / Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages / Curr Opin Immunol 21:514~521
Bhattacharya P / 2015 / Dual Role of GM-CSF as a pro-inflammatory and a regulatory cytokine: implications for immune therapy / J Interferon Cytokine Res 35:585~599
Hoffmann M / 2020 / SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor / Cell 181:271~280
Bonaventura A / 2020 / Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies / Front Immunol 1:1625
Trapnell BC / 2009 / Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages / Curr Opin Immunol 21:514~521
Bhattacharya P / 2015 / Dual Role of GM-CSF as a pro-inflammatory and a regulatory cytokine: implications for immune therapy / J Interferon Cytokine Res 35:585~599
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