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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 11 - 18 (8page)
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초록· 키워드
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Objective Many patients suffer from dementia in its most common form, Alzheimer’s disease (AD). In this study, the levels of IL-1β, TGF-β and CRP, which are involved in the inflammatory response in Alzheimer’s disease and its mild cognitive impairment (MCI), were measured and analyzed.Methods Seventy nine subjects participated in this study (mean age: 75.56 years, female: 54.3%, AD: 26, MCI: 28, normal: 25). The overall cognitive function of the subjects and the severity of the disease stage were assessed using the Mini-Mental State Examination (MMSE-K), the Clinical Dementia Rating (CDR), the Global Deterioration Scale (GDS) and the Geriatric Depression Scale-Korean (GDS-K).Results It was observed that patients with AD had significantly higher levels of IL-1β and TGF-β than the patients with MCI and normal controls. In addition, the MCI group showed a statistically significantly higher TGF-β concentration than the normal group.Conclusion These results suggest that IL-1β and TGF-β may be useful biological markers for patients with Alzheimer’s disease.
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참고문헌 (59)
참고문헌 신청
Hampel H / 2011 / The future of Alzheimer’s disease : The next 10 years / Prog Neurobiol 95:718~728
Fu Y / 2014 / Protein-Based biomarkers in cerebrospinal fluid and blood for Alzheimer’s disease / J Mol Neurosci 54:739~747
Alzheimer’s Association / 2013 / 2013 Alzheimer’s disease facts and figures / Alzheimers Dement 9:208~245
Pedro C / 2016 / Blood-based biomarkers of Alzheimer’s disease : diagnostic algorithms and new technologies / Curr Alzheimer Res 13:450~464
Dubois B / 2013 / Alzheimer’s disease : from biomarkers to diagnosis / Rev Neurology 169:744~751
Fu Y / 2014 / Protein-Based biomarkers in cerebrospinal fluid and blood for Alzheimer’s disease / J Mol Neurosci 54:739~747
Alzheimer’s Association / 2013 / 2013 Alzheimer’s disease facts and figures / Alzheimers Dement 9:208~245
Pedro C / 2016 / Blood-based biomarkers of Alzheimer’s disease : diagnostic algorithms and new technologies / Curr Alzheimer Res 13:450~464
Dubois B / 2013 / Alzheimer’s disease : from biomarkers to diagnosis / Rev Neurology 169:744~751
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