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논문 기본 정보

자료유형
학술저널
저자정보
Wang Sheng-Min (Department of Psychiatry Yeouido St. Mary’s Hospital College of Medicine The Catholic University of) Park See Hyun (Department of Pharmacology College of Medicine The Catholic University of Korea) Kim Nak-Young (Department of Psychiatry Keyo Hospital) Kang Dong Woo (Department of Psychiatry Seoul St. Mary’s Hospital College of Medicine The Catholic University of K) Na Hae-Ran (Department of Psychiatry Yeouido St. Mary’s Hospital College of Medicine The Catholic University of) Um Yoo Hyun (Department of Psychiatry St. Vincent Hospital College of Medicine The Catholic University of Korea) Han Seunghoon (Department of Pharmacology College of Medicine The Catholic University of Korea) Park Sung-Soo (Department of Hematology Seoul St. Mary’s Hospital College of Medicine The Catholic University of K) Lim Hyun Kook (Department of Psychiatry Yeouido St. Mary’s Hospital College of Medicine The Catholic University of)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제18권 제6호
발행연도
2021.1
수록면
523 - 529 (7page)

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Objective Despite a high prevalence of dementia in older adults hospitalized with severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2), or so called COVID-19, research investigating association between preexisting diagnoses of dementia and prognosis of COVID-19 is scarce. We aimed to investigate treatment outcome of patients with dementia after COVID-19. Methods We explored a nationwide cohort with a total of 2,800 subjects older than 50 years who were diagnosed with COVID-19 between January and April 2020. Among them, 223 patients had underlying dementia (dementia group). We matched 1:1 for each dementia- non-dementia group pair yielding 223 patients without dementia (no dementia group) using propensity score matching. Results Mortality rate after COVID-19 was higher in dementia group than in no dementia group (33.6% vs. 20.2%, p=0.002). Dementia group had higher proportion of patients requiring invasive ventilatory support than no dementia group (34.1% vs. 22.0%, p=0.006). Multivariable analysis showed that dementia group had a higher risk of mortality than no dementia group (odds ratio=3.05, p<0.001). We also found that patients in dementia group had a higher risk of needing invasive ventilatory support than those in no dementia group. Conclusion Our results suggest that system including strengthen quarantines are required for patients with dementia during the COVID- 19 pandemic.
#SARS-CoV-2 #COVID-19 #Dementia #Mortality.

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참고문헌 (31)

참고문헌 신청
Wiersinga WJ / 2020 / Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019(COVID-19) : a review / JAMA 324:782~793 google schola Tian W / 2020 / Predictors of mortality in hospitalized COVID-19 patients : A systematic review and meta-analysis / J Med Virol 92:1875~1883 google schola Li X / 2020 / Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan / J Allergy Clin Immunol 146:110~118 google schola Yang JM / 2020 / Allergic disorders and susceptibility to and severity of COVID-19 : A nationwide cohort study / J Allergy Clin Immunol 146:790~798 google schola Zhou F / 2020 / Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China : a retrospective cohort study / Lancet 395:1054~1062 google schola

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