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논문 기본 정보

자료유형
학술저널
저자정보
Yu Rim Lee (Kyungpook National University) Min Kyu Kang (Department of Internal Medicine Yeungnam University College of Medicine) Jeong Eun Song (Department of Internal Medicine Daegu Catholic University School of Medicine) Hyun Jung Kim (Department of Internal Medicine Keimyung University School of Medicine) Young Oh Kweon (Department of Internal Medicine School of Medicine Kyungpook National University) Won Young Tak (Department of Internal Medicine School of Medicine Kyungpook National University) Se Young Jang (Department of Internal Medicine School of Medicine Kyungpook National University) Jung Gil Park (Department of Internal Medicine Yeungnam University College of Medicine) Chang Hyeong Lee (Department of Internal Medicine Daegu Catholic University School of Medicine) Jae Seok Hwang (Department of Internal Medicine Keimyung University School of Medicine) Byoung Kuk Jang (Department of Internal Medicine Keimyung University School of Medicine) Jeong Ill Suh (Dongguk University) Woo Jin Chung (Department of Internal Medicine Keimyung University School of Medicine) Byung Seok Kim (Department of Internal Medicine Daegu Catholic University School of Medicine) Soo Young Park (Department of Internal Medicine School of Medicine Kyungpook National University)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제26권 제4호
발행연도
2020.1
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562 - 576 (15page)

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Background/Aims: Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver disease on the outcome of COVID-19 remains unresolved. Methods: A total of 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed COVID-19 were included in this study. Clinical outcomes in COVID-19 patients with coexisting liver disease as well as the predictors of disease severity and mortality of COVID-19 were assessed. Results: Of the 47 patients (4.7%) who had liver-related comorbidities, 14 patients (1.4%) had liver cirrhosis. Liver cirrhosis was more common in COVID-19 patients with severe pneumonia than in those with non-severe pneumonia (4.5% vs. 0.9%, P=0.006). Compared to patients without liver cirrhosis, a higher proportion of patients with liver cirrhosis required oxygen therapy; were admitted to the intensive care unit; had septic shock, acute respiratory distress syndrome, or acute kidney injury; and died (P<0.05). The overall survival rate was significantly lower in patients with liver cirrhosis than in those without liver cirrhosis (log-rank test, P=0.003). Along with old age and diabetes, the presence of liver cirrhosis was found to be an independent predictor of severe disease (odds ratio, 4.52; 95% confidence interval [CI], 1.20?17.02; P=0.026) and death (hazard ratio, 2.86; 95% CI, 1.04?9.30; P=0.042) in COVID-19 patients. Conclusions: This study suggests liver cirrhosis is a significant risk factor for COVID-19. Stronger personal protection and more intensive treatment for COVID-19 are recommended in these patients.
#Liver diseases #Liver cirrhosis #Prognosis #Mortality #COVID-19

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참고문헌 (29)

참고문헌 신청
World Health Organization (WHO) / Coronavirus disease (COVID-19)Situation Report – 134 / WHO web site google schola Chen N / 2020 / Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China : a descriptive study / Lancet 395:507~513 google schola Guan WJ / 2020 / Clinical characteristics of coronavirus disease 2019 in China / N Engl J Med 382:1708~1720 google schola Wang D / 2020 / Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirusinfected pneumonia in Wuhan, China / JAMA 323:1061~1069 google schola Wang B / 2020 / Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis / Aging (Albany NY) 12:6049~6057 google schola

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