지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Despite the high discontinuation rate of clozapine in refractory schizophrenia, there is limited evidence regarding the suggested treatment after clozapine discontinuation. Methods: The medical records of 37 patients who discontinued clozapine were retrospectively reviewed. The prescription patterns of antipsychotics, mood stabilizers, and antidepressants were compared at three points before and after clozapine treatment and at the most recent visit. Results: After clozapine discontinuation, 75.6% of the subjects were receiving antipsychotic polypharmacy, and 32.4% were taking more than 3 antipsychotics. The frequently used antipsychotics were olanzapine (21.5%), quetiapine (21.5%), and paliperidone (12.7%). The rates of augmentation with mood stabilizers and antidepressants were 43.2% and 29.7%, respectively. Furthermore, valproate was the most commonly used mood stabilizer (87.5%). Conclusion: Antipsychotic polypharmacy and augmentation are inevitable in schizophrenia patients for whom clozapine has been discontinued. Further research is required to improve the outcomes of polypharmacy and augmentation in schizophrenia patients.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
National Collaborating Centre for Mental Health (UK) / 2014 / Psychosis and Schizophrenia in Adults: Treatment and Management: Updat-ed Edition 2014
McIlwain ME / 2011 / Pharmaco-therapy for treatment-resistant schizophrenia / Neuropsychiatr Dis Treat 7:135~149
Lewis SW / 2006 / Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in re-sistant schizophrenia / Schizophr Bull 32:715~723
McEvoy JP / 2006 / Effectiveness of clozapine versus olanzap-ine, quetiapine, and risperidone in patients with chronic schizo-phrenia who did not respond to prior atypical antipsychotic treat-ment / Am J Psychiatry 163:600~610
Lieberman JA / 2005 / Effectiveness of antipsychotic drugs in patients with chronic schizophrenia / N Engl J Med 353:1209~1223
McIlwain ME / 2011 / Pharmaco-therapy for treatment-resistant schizophrenia / Neuropsychiatr Dis Treat 7:135~149
Lewis SW / 2006 / Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in re-sistant schizophrenia / Schizophr Bull 32:715~723
McEvoy JP / 2006 / Effectiveness of clozapine versus olanzap-ine, quetiapine, and risperidone in patients with chronic schizo-phrenia who did not respond to prior atypical antipsychotic treat-ment / Am J Psychiatry 163:600~610
Lieberman JA / 2005 / Effectiveness of antipsychotic drugs in patients with chronic schizophrenia / N Engl J Med 353:1209~1223
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