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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 128 - 135 (8page)
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초록· 키워드
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Inflammatory bowel disease (IBD), comprised of Crohn’s disease and ulcerative colitis, is a chronic, relapsing, and remitting disease of the gastrointestinal tract whose incidence is rising worldwide, especially in East Asian countries. The etiopathogenesis of IBD remains poorly understood. It is currently considered that a combination of genetic and environmental factors triggers an aberrant immune response against the commensal intestinal flora in IBD patients. Over the past decades, advances in the knowledge of the inflammatory cascade involved in IBD pathogenesis have expanded the pharmacological armamentarium in IBD. Actually, the introduction of specific biological therapies, including anti- tumor necrosis factor, anti-interleukin- 12/23, and anti-integrin, has revolutionized the treatment of IBD. Moreover, small molecule agents such as Janus kinase inhibitors also now under clinical use. In IBD, a substantial number of patient accompanies various articular manifestations and, rheumatic involvement is one of the most common extra-intestinal symptoms. Many of the mechanisms based drugs described above have already been used in rheumatic diseases. In addition, some of those drugs can be used to treat both IBD itself and accompanied rheumatic involvement, however there are differences in drug usage between these two indications. This review aims to briefly review the mechanism-based drug therapies of IBD with particular reference to rheumatic disease.
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등록된 정보가 없습니다.
참고문헌 (73)
참고문헌 신청
Ng SC / 2018 / Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century : a systematic review of population-based studies / Lancet 390:2769~2778
Xavier RJ / 2007 / Unravelling the pathogenesis of inflammatory bowel disease / Nature 448:427~434
Torres J / 2017 / Crohn’s disease / Lancet 389:1741~1755
Ungaro R / 2017 / Ulcerative colitis / Lancet 389:1756~1770
Ott C / 2013 / Extraintestinal manifestations and complications in IBD / Nat Rev Gastroenterol Hepatol 10:585~595
Xavier RJ / 2007 / Unravelling the pathogenesis of inflammatory bowel disease / Nature 448:427~434
Torres J / 2017 / Crohn’s disease / Lancet 389:1741~1755
Ungaro R / 2017 / Ulcerative colitis / Lancet 389:1756~1770
Ott C / 2013 / Extraintestinal manifestations and complications in IBD / Nat Rev Gastroenterol Hepatol 10:585~595
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