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논문 기본 정보

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학술저널
저자정보
Kim Seong Eun (Departments of Infectious Diseases Chonnam National University Hospital Gwangju Korea.) Lee Ji Yeon (Department of Infectious Diseases Keimyung University Dongsan Hospital Daegu Korea.) Lee Ahrang (Departments of Infectious Diseases Chonnam National University Hospital Gwangju Korea.) Kim Soosung (Departments of Infectious Diseases Chonnam National University Hospital Gwangju Korea.) Park Kyung-Hwa (Departments of Infectious Diseases Chonnam National University Hospital Gwangju Korea.) Jung Sook-In (Departments of Infectious Diseases Chonnam National University Hospital Gwangju Korea.) Kang Seung-Ji (Department of Infectious Diseases Chonnam National University Bitgoeul Hospital Gwangju Korea.) Oh Tae Hoon (Department of Infectious Diseases Chonnam National University Hwasun Hospital Hwasun Korea.) Kim Uh Jin (Department of Infectious Diseases Chonnam National University Hwasun Hospital Hwasun Korea.) Lee Seung Yeob (Department of Laboratory Medicine Chonnam National University Hospital Gwangju Korea.) Kee Seung-Jung (Department of Laboratory Medicine Chonnam National University Hospital Gwangju Korea.) 장희창 (전남대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.35 No.31
발행연도
2020.1
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1 - 8 (8page)

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Background: This study was performed to compare the viral load and kinetics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in saliva with those in standard nasopharyngeal/oropharyngeal (NP/OP) swabs. Methods: Fifteen patients with SARS-CoV-2 infection from four hospitals were prospectively enrolled and matched samples of nasopharyngeal/oropharyngeal swabs and saliva were collected at Day 1 of admission and every other day till consequently negative for two times. Real-time reverse transcription polymerase chain reaction (rRT-PCR) was performed to detect the envelope (E) and RNA-dependent RNA polymerase (RdRP) genes. Results: The cycle threshold values of saliva were comparable to those of NP/OP swabs overall (P = 0.720, Mann–Whitney U test). However, the overall sensitivity of rRT-PCR using saliva was 64% (34/53), which is lower than the 77% (41/53) using NP/OP swabs. The sensitivity of rRT-PCR using saliva was especially lower in early stage of symptom onset (1–5 days; 8/15; 53%) and in patients who did not have sputum (12/22; 55%). Conclusion: Saliva sample itself is not appropriate for initial diagnosis of coronavirus disease 2019 (COVID-19) to replace NP/OP swabs, especially for the person who does not produce sputum. COVID-19 cannot be excluded when the test using saliva is negative, and it is necessary to retest using NP/OP swabs.
#SARS-CoV-2 PCR #Saliva #Nasopharyngeal Swab #Oropharyngeal Swab

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참고문헌 (20)

참고문헌 신청
U.S. Food and Drug Administration / Accelerated emergency use authorization (EUA) summary. SARSCoV-2 assay (Rutgers Clinical Genomics Laboratory) google schola Azzi L / 2020 / Saliva is a reliable tool to detect SARS-CoV-2 / J Infect 81(1):e45~e50 google schola Pasomsub E / 2020 / Saliva sample as a non-invasive specimen for the diagnosis of coronavirus disease 2019: a cross-sectional study / Clin Microbiol Infect. Crossref Tu YP / Patient-collected tongue, nasal, and mid-turbinate swabs for SARS-CoV-2 yield equivalent sensitivity to health care worker collected nasopharyngeal swabs google schola Wyllie AL / 2020 / Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs / medRxiv. https://doi.org/10.1101/2020.04.16.20067835 google schola

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