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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 143 - 147 (5page)
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초록· 키워드
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The various functional properties of chitosan have been investigated for use in biomedical applications. Indeed, chitosan or its derivatives have shown anti-inflammatory effect by regulating a range of cytokines, chemokines or growth factors. In the present study, we prepared water-soluble chitosan oligosaccharide (AS-WSC) by the hydrolysis of high molecular weight water-soluble chitosan (HMW-WSC) and examined its anti-inflammatory effect on LPS-stimulated human monocytic THP-1 cells. Our results revealed that LPS-induced NF-κB activity of THP-1 cells was significantly suppressed by treatment with 0.02% AS-WSC. In addition, 0.02% AS-WSC treatment down-regulated the expression of Toll-like receptor 4 and inflammatory cytokines, such as IL-1β and TNF-α, but had no effect on IL-10 and IL-4 expression in LPS-stimulated THP-1 cells. Our results suggest that 0.02% AS-WSC can be considered as a promising anti-inflammatory agent.
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참고문헌 (23)
참고문헌 신청
Koide, S.S. / 1998 / Chitin-chitosan: properties, benefits and risks / Nutr. Res. 18:1091~1101
Younes, I. / 2015 / Chitin and chitosan preparation from marine sources. Structure, properties and applications / Mar. Drugs 13:1133~1174
Kaczmarek, M. B. / 2019 / Enzymatic Modifications of Chitin, Chitosan, and Chitooligosaccharides / Front. Bioeng. Biotechnol 7:243
Cheung, R. C. / 2015 / Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications / Marine drugs 13(8):5156~5186
Majekodunmi, S.O. / 2016 / Current development of extraction, characterization and evaluation of properties of chitosan and its use in medicine and pharmaceutical industry / Am. J. Polym. Sci 6:86~91
Younes, I. / 2015 / Chitin and chitosan preparation from marine sources. Structure, properties and applications / Mar. Drugs 13:1133~1174
Kaczmarek, M. B. / 2019 / Enzymatic Modifications of Chitin, Chitosan, and Chitooligosaccharides / Front. Bioeng. Biotechnol 7:243
Cheung, R. C. / 2015 / Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications / Marine drugs 13(8):5156~5186
Majekodunmi, S.O. / 2016 / Current development of extraction, characterization and evaluation of properties of chitosan and its use in medicine and pharmaceutical industry / Am. J. Polym. Sci 6:86~91
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