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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 406 - 414 (9page)
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초록· 키워드
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Background: Metabolically healthy obese (MHO) is regarded as a transient concept. We examined the effect of the dynamic changeof metabolic health status on the incidence of type 2 diabetes mellitus (T2DM) both in obese and normal weight individuals. Methods: We analyzed 3,479,514 metabolically healthy subjects aged over 20 years from the Korean National Health ScreeningProgram, who underwent health examination between 2009 and 2010, with a follow-up after 4 years. The relative risk for T2DM incidence until the December 2017 was compared among the four groups: stable metabolically healthy normal weight (MHNW), unstable MHNW, stable MHO, and unstable MHO. Results: During the 4 years, 11.1% of subjects in the MHNW group, and 31.5% in the MHO group converted to a metabolically unhealthy phenotype. In the multivariate adjusted model, the unstable MHO group showed the highest risk of T2DM (hazard ratio[HR], 4.67; 95% confidence interval [CI], 4.58 to 4.77). The unstable MHNW group had a higher risk of T2DM than stable MHOgroup ([HR, 3.23; 95% CI, 3.16 to 3.30] vs. [HR, 1.81; 95% CI, 1.76 to 1.85]). The stable MHO group showed a higher risk ofT2DM than the stable MHNW group. The influence of the transition into a metabolically unhealthy phenotype on T2DM incidencewas greater in subjects with aged <65 years, women, and those with weight gain. Conclusion: Metabolically healthy phenotype was transient both in normal weight and obese individuals. Maintaining metabolichealth was critical for the prevention of T2DM, irrespective of their baseline body mass index
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참고문헌 (32)
참고문헌 신청
Ranasinghe P / 2017 / Prevalence and trends of metabolic syndrome among adults in the Asia-Pacific region : a systematic review / BMC Public Health 17:101
Iacobini C / 2019 / Metabolically healthy versus metabolically unhealthy obesity / Metabolism 92:51~60
Hinnouho GM / 2015 / Metabolically healthy obesity and the risk of cardiovascular disease and type 2 diabetes : the Whitehall II cohort study / Eur Heart J 36:551~559
Aung K / 2014 / Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals / J Clin Endocrinol Metab 99:462~468
Lassale C / 2018 / Separate and combined associations of obesity and metabolic health with coronary heart disease : a pan-European case-cohort analysis / Eur Heart J 39:397~406
Iacobini C / 2019 / Metabolically healthy versus metabolically unhealthy obesity / Metabolism 92:51~60
Hinnouho GM / 2015 / Metabolically healthy obesity and the risk of cardiovascular disease and type 2 diabetes : the Whitehall II cohort study / Eur Heart J 36:551~559
Aung K / 2014 / Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals / J Clin Endocrinol Metab 99:462~468
Lassale C / 2018 / Separate and combined associations of obesity and metabolic health with coronary heart disease : a pan-European case-cohort analysis / Eur Heart J 39:397~406
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