지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 451 - 458 (8page)
이용수
초록· 키워드
오류제보하기
Background: Recently, there have been some trials to use dexmedetomidine in the obstetric field but concerns regarding the drug include changes in uterine contractions after labor. We aimed to evaluate the effects of dexmedetomidine on the myometrial contractions of pregnant rats.Methods: In a pilot study, the contraction of the myometrial strips of pregnant Sprague-Dawley rats in an organ bath with oxytocin at 1 mU/ml was assessed by adding dexmedetomidine from 10-6 to 10-2 M accumulatively every 20 min, and active tension and the number of contractions were evaluated. Then, changes in myometrial contractions were evaluated from high doses of dexmedetomidine (1.0 × 10−4 to 1.2 × 10−3 M). The effective concentrations (EC) for changes in uterine contractions were calculated using a probit model.Results: Active tension and the number of contractions were significantly decreased at 10-3 M and 10-4 M dexmedetomidine, respectively (P < 0.05). A complete loss of contractions was seen at 10-2 M. Dexmedetomidine (1.0 × 10−4 to 1.2 × 10−3 M) decreased active tension and the number of contractions in a concentration-dependent manner. The EC95 of dexmedetomidine for inhibiting active tension and the number of contractions was 5.16 × 10-2 M and 2.55 × 10-5 M, respectively.Conclusions: Active tension of the myometrium showed a significant decrease at concentrations of dexmedetomidine higher than 10-3 M. Thus, clinical concentrations of dexmedetomidine may inhibit uterine contractions. Further research is needed for the safe use of dexmedetomidine in the obstetrics field.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
이성헌 / 2019 / Dexmedetomidine: present and future directions / Korean Journal of Anesthesiology 72(4):323~330
Nair AS / 2013 / Dexmedetomidine in pregnancy : review of literature and possible use / J Obstet Anaesth Crit Care 3:3~6
Mendoza Villa JM / 2012 / Dexmedetomidine as adjunct for analgesia in labor : a report of two cases / Rev Colomb Anestesiol 40:79~81
El-Arab NKE / 2017 / Dexmedetomidine in preeclamptic patients undergoing caesarean section under general anesthesia / Tanta Med J 45:220~225
Mishra N / 2016 / Intravenous dexmedetomidine for labour analgesia in women with preeclampsia / J Evol Med Dent Sci 5:3408~3411
Nair AS / 2013 / Dexmedetomidine in pregnancy : review of literature and possible use / J Obstet Anaesth Crit Care 3:3~6
Mendoza Villa JM / 2012 / Dexmedetomidine as adjunct for analgesia in labor : a report of two cases / Rev Colomb Anestesiol 40:79~81
El-Arab NKE / 2017 / Dexmedetomidine in preeclamptic patients undergoing caesarean section under general anesthesia / Tanta Med J 45:220~225
Mishra N / 2016 / Intravenous dexmedetomidine for labour analgesia in women with preeclampsia / J Evol Med Dent Sci 5:3408~3411
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Dexmedetomidine: present and future directions
Korean Journal of Anesthesiology
2019 .01
-
Factors to bear in mind regarding the use of dexmedetomidine
Korean Journal of Anesthesiology
2017 .01
-
Dexmedetomidine combined with midazolam vs. dexmedetomidine alone for sedation during spinal anesthesia
Korean Journal of Anesthesiology
2016 .01
-
Intranasally Administered Adjunctive Dexmedetomidine Reduces Perioperative Anesthetic Requirements in General Anesthesia
Yonsei Medical Journal
2016 .01
-
Less explored off-label indications of dexmedetomidine
Korean Journal of Anesthesiology
2017 .01
-
Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats
International Neurourology Journal
2017 .01
-
Optimal dose of dexmedetomidine for sedation during epidural anesthesia
Anesthesia and Pain Medicine
2017 .01
-
Pre-anesthetic sedative effect of dexmedetomidine in laparoscopic cholecystectomy performed under general anesthesia
Anesthesia and Pain Medicine
2018 .01
-
Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial
Korean Journal of Anesthesiology
2021 .01
-
The effect of dexmedetomidine sedation on patient and surgeon satisfaction during retinal surgery under sub-tenon’s anesthesia : a randomized controlled trial
Korean Journal of Anesthesiology
2015 .01
-
Dexmedetomidine Modulates Histamine-induced Ca2+ Signaling and Pro-inflammatory Cytokine Expression
The Korean Journal of Physiology & Pharmacology
2015 .09
-
Dexmedetomidine for sedation in pediatric patients who received more than 20 sessions of radiation therapy -two cases report-
Korean Journal of Anesthesiology
2016 .01
-
Role of dexmedetomidine in pediatric dental sedation
Journal of dental anesthesia and pain medicine
2019 .01
-
Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Application of Monitored Anesthesia Care Using Dexmedetomidine to Common Oral and Maxillofacial Trauma Cases
Journal of Korean Dental Science
2017 .12
-
Effective dose of dexmedetomidine to induce adequate sedation in elderly patients under spinal anesthesia
Korean Journal of Anesthesiology
2015 .01
-
Effect of different contraction methods on pelvic floor muscle contraction in middle-aged women
Physical therapy rehabilitation science
2015 .01
-
A Cost-Minimization Analysis Comparing Dexmedetomidine with Midazolam and Propofol for Sedation in Mechanically Ventilated Intensive Care Unit Patients
보건의료기술평가
2016 .12
-
The Effectiveness of Dexmedetomidine in Vacuum-Assisted Breast Biopsy Under Monitored Anesthesia Care
고신대학교 의과대학 학술지
2019 .01
-
Efficacy of intraoperative dexmedetomidine infusion on visualization of the surgical field in endoscopic sinus surgery
Korean Journal of Anesthesiology
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0