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학술저널
저자정보
Fabien Wuestenberghs (Department of Gastroenterology and Hepatology CHU UCL Namur Godinne University Hospital UCLouvain Y) Mathilde Juge (Department of Gastroenterology Rouen University Hospital Normandie University Rouen France) Chloé Melchior (Nutrition Gut and Brain Laboratory (INSERM UMR 1073) Institute for Biomedical Research and innovati) Charlotte Desprez (Department of Physiology Rouen University Hospital Normandie University Rouen France) Anne-Marie Leroi (5Department of Physiology INSERM CIC-CRB 1404 Rouen University Hospital INSERM Unit 1073 UNIROUEN N) Guillaume Gourcerol (Department of Physiology Rouen University Hospital Normandie University Rouen France)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.25 No.4
발행연도
2019.1
수록면
534 - 543 (10page)

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Background/Aims Association between symptoms, quality of life and gastric emptying in dyspepsia is inconsistent in the literature. The aim of our study is to investigate if gastric emptying is associated with specific symptoms and quality of life in dyspeptic patients. Methods We reviewed retrospectively gastric emptying measured by 13C-labelled octanoate breath testing for more than 6 hours in 198 consecutive patients with dyspepsia complaints. Gastrointestinal symptoms were assessed using a 5-points Likert scale and by a symptomatic composite score, whereas quality of life was measured by the GIQLI. Results In our cohort, 90 patients (45%) had a delayed gastric emptying (half emptying time above 166 minutes when assessed over 6–8 hours). There was no difference in symptoms or quality of life between patients with or without delayed gastric emptying. However, patients with severely delayed gastric emptying (half emptying time above 200 minutes) had increased postprandial fullness (P = 0.012), abdominal pain (P = 0.026), bloating (P = 0.044), early satiety (P = 0.018), symptomatic composite score (P = 0.005), and a lower quality of life (P = 0.018). This association was no longer observed if the calculation of gastric emptying was limited to the first 4-hour samples. Conclusions There is no association between symptoms, quality of life and gastric emptying in an overall dyspeptic population. However, there is an association between symptoms, quality of life of delayed gastric emptying in the subgroup of patients with severely delayed gastric emptying. An 8-hour measurement of gastric emptying should be recommended.

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