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TGF-β is a multifunctional cytokine that plays an important role in both physiologic and pathologic processes, including cancer. Importantly, TGF-β has a dual role in tumorigenesis, acting as a tumor suppressor or a tumor promoter, depending on the stage of tumor development. The aberrantly upregulated production of TGF-β has been strongly implicated in tumor progression, angiogenesis, and metastasis, as well as immune evasion. Therefore, hyperactivated TGF-β signaling is considered a potential therapeutic target for cancer therapy. Numerous inhibitors of overactivated TGF-β signaling have been developed, and some of them are currently in clinical trials. This review focuses on the TGF-β signaling that contributes to tumor progression and immune evasion in the tumor microenvironment and presents recent achievements on TGF-β signaling inhibition as a single or combined therapeutic approach in cancer therapy. Key Words TGF-b, Tumor microenvironment, Tumor escape, Antineoplastic agents, Immune checkpoint inhibitors
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참고문헌 (85)
참고문헌 신청
Moses HL / 1981 / Transforming growth factor production by chemically transformed cells / Cancer Res 41:2842~2848
Roberts AB / 2002 / The ever-increasing complexity of TGF-beta signaling / Cytokine Growth Factor Rev 13:3~5
Massagué J / 2000 / TGFbeta signaling in growth control, cancer, and heritable disorders / Cell 103:295~309
David CJ / 2018 / Contextual determinants of TGFβ action in development, immunity and cancer / Nat Rev Mol Cell Biol 19:419~435
Zhao H / 2020 / Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy / Int Immunopharmacol
Roberts AB / 2002 / The ever-increasing complexity of TGF-beta signaling / Cytokine Growth Factor Rev 13:3~5
Massagué J / 2000 / TGFbeta signaling in growth control, cancer, and heritable disorders / Cell 103:295~309
David CJ / 2018 / Contextual determinants of TGFβ action in development, immunity and cancer / Nat Rev Mol Cell Biol 19:419~435
Zhao H / 2020 / Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy / Int Immunopharmacol
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