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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 210 - 217 (8page)
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Background/Aims: The exact relationship between vitamin D deficiency and inflammatory bowel disease (IBD) remains unclear. We evaluated the effect of vitamin D3 administration on inflammatory responses and disease severity in patients with IBD. Methods: We investigated the serum 25-hydroxyvitamin D3 [25-(OH)D], C-reactive protein (CRP) levels and the partial Mayo score (PMS) in patients with IBD. Vitamin D3 was administered in patients with either vitamin D deficiency or insufficiency and CRP, serum vitamin D levels and PMS were re-examined at 6 months of administration. Results: In 88 patients with Crohn’s disease (CD), a negative correlation was found between serum vitamin D and CRP. In 178 patients with ulcerative colitis (UC), serum vitamin D showed no association with CRP or PMS. Serum vitamin D increased from 11.08±3.63 to 22.69±6.11 ng/mL in 29 patients with CD and from 11.45±4.10 to 24.20±6.61 ng/mL in 41 patients with UC who received vitamin D3 treatment (P<0.001 and P<0.001, respectively). In patients with CD, median ΔCRP was –0.24 in the normalized vitamin D group and –0.11 in the non-normalized group (P=0.308). In patients with UC, median ΔCRP was −0.01 in the normalized vitamin D group and 0.06 in the non-normalized group (P=0.359). Conclusions: Although a negative correlation was found between serum vitamin D and CRP levels in patients with CD, administration of vitamin D did not improve the CRP level in patients with CD. In patients with UC, serum vitamin D level was unrelated to CRP or PMS. (Intest Res 2019;17:210-217)
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참고문헌 (25)
참고문헌 신청
Abraham C / 2009 / Inflammatory bowel disease / N Engl J Med 361:2066~2078
Khor B / 2011 / Genetics and pathogenesis of inflammatory bowel disease / Nature 474:307~317
Jones G / 1998 / Current understanding of the molecular actions of vitamin D / Physiol Rev 78:1193~1231
Sadeghian M / 2016 / Vitamin D status in relation to Crohn’s disease : meta-analysis of observational studies / Nutrition 32:505~514
한유민 / 2017 / Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease / Gut and Liver 11(3):363~369
Khor B / 2011 / Genetics and pathogenesis of inflammatory bowel disease / Nature 474:307~317
Jones G / 1998 / Current understanding of the molecular actions of vitamin D / Physiol Rev 78:1193~1231
Sadeghian M / 2016 / Vitamin D status in relation to Crohn’s disease : meta-analysis of observational studies / Nutrition 32:505~514
한유민 / 2017 / Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease / Gut and Liver 11(3):363~369
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