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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 441 - 451 (11page)
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Background: Although bone tissue engineering has already been applied clinically, its regeneration efficacy is not always sufficient. Local inflammatory cytokines are considered as the major factors that induce apoptosis of transplanted cells, thus leading to insufficient new bone formation. In this study, we focused on the effects of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) on differentiation and apoptosis of compact bone-derived cells (CBDCs). Methods: CBDCs were obtained from mouse legs and cultured. The effects of TNF-α and/or IL-6 on the osteogenic differentiation and apoptosis of CBDCs were analyzed in vitro. To confirm the expression of local inflammatory cytokines in vivo, CBDCs were transplanted to the back of immunocompetent mice. Results: IL-6 exerted inconsistent effects on the expression of the different osteogenic markers tested, while significantly upregulating Fas. By contrast, the addition of TNF-α dramatically reduced the expression of all tested osteogenic markers and increased Fas expression. The highest dose of IL-6 could partially reverse the repressive effect of TNF-α, while the addition of IL-6 further increased Fas expression in CBDCs compared to TNF-α alone. The results from in vivo experiments showed the presence of transplants with and without new bone formation. The transplants without bone formation were characterized by higher IL-6 and lower IL-10 expression than those with bone formation, while the expression of TNF-α did not show notable difference. Conclusion: The results of this study suggest an important role for IL-6 in modulating the efficacy of bone tissue engineering, which can affect osteogenic cells both positively and negatively.
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참고문헌 (40)
참고문헌 신청
Kagami H / 2014 / The use of bone marrow stromal cells(bone marrowderived multipotent mesenchymal stromal cells)for alveolar bone tissue engineering : basic science to clinical translation / Tissue Eng Part B Rev 20:229~232
Gjerde C / 2018 / Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial / Stem Cell Res Ther 9:213
Bajestan MN / 2017 / Stem cell therapy for reconstruction of alveolar cleft and trauma defects in adults : a randomized controlled, clinical trial / Clin Implant Dent Relat Res 19:793~801
Liu Y / 2011 / Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-c and TNF-a / Nat Med 17:1594~1601
Kanazawa S / 2013 / Tissue responses against tissue-engineered cartilage consisting of chondrocytes encapsulated within non-absorbable hydrogel / J Tissue Eng Regen Med 7:1~9
Gjerde C / 2018 / Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial / Stem Cell Res Ther 9:213
Bajestan MN / 2017 / Stem cell therapy for reconstruction of alveolar cleft and trauma defects in adults : a randomized controlled, clinical trial / Clin Implant Dent Relat Res 19:793~801
Liu Y / 2011 / Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-c and TNF-a / Nat Med 17:1594~1601
Kanazawa S / 2013 / Tissue responses against tissue-engineered cartilage consisting of chondrocytes encapsulated within non-absorbable hydrogel / J Tissue Eng Regen Med 7:1~9
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