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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,828 - 1,837 (10page)
이용수
초록· 키워드
오류제보하기
Thromboprophylaxis for venous thromboembolism is widely used in critically ill patients. However, only limited evidence exists regarding the efficacy and safety of the various thromboprophylaxis techniques, especially mechanical thromboprophylaxis. Therefore, we performed meta-analysis of randomized controlled trials (RCTs) that compared the overall incidence of deep vein thrombosis (DVT) for between unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), and intermittent pneumatic compression (IPC) in critically ill patients. A Bayesian random effects model for multiple treatment comparisons was constructed. The primary outcome measure was the overall incidence of DVT at the longest follow-up. The secondary outcome measure was the incidence of major bleeding, as defined by the original trials. Our analysis included 8,622 patients from 12 RCTs. The incidence of DVT was significantly lower in patients treated with UFH (OR, 0.45; 95% CrI, 0.22–0.83) or LMWH (OR, 0.38; 95% CrI, 0.18–0.72) than in patients in the control group. IPC was associated with a reduced incidence of DVT compared to the control group, but the effect was not statistically significant (OR, 0.50; 95% CrI, 0.20–1.23). The risk of DVT was similar for patients treated with UFH and LMWH (OR, 1.16; 95% CrI, 0.68–2.11). The risk of major bleeding was similar between the treatment groups in medical critically ill patients and also in critically ill patients with a high risk of bleeding. In critically ill patients, the efficacy of mechanical thromboprophylaxis in reducing the risk of DVT is not as robust as those of pharmacological thromboprophylaxis.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Moser KM / 1981 / Deep venous thrombosis and pulmonary embolism. Frequency in a respiratory intensive care unit / JAMA 246:1422~1424
Geerts W / 2002 / Venous thromboembolism and its prevention in critical care / J Crit Care 17:95~104
Cook DJ / 2010 / Pulmonary embolism in medical-surgical critically ill patients / Hematol Oncol Clin North Am 24:677~682
Kahn SR / 2012 / Prevention of VTE in nonsurgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines / Chest 141:e195S~e226S
Alhazzani W / 2013 / Heparin thromboprophylaxis in medical-surgical critically ill patients : a systematic review and meta-analysis of randomized trials / Crit Care Med 41:2088~2098
Geerts W / 2002 / Venous thromboembolism and its prevention in critical care / J Crit Care 17:95~104
Cook DJ / 2010 / Pulmonary embolism in medical-surgical critically ill patients / Hematol Oncol Clin North Am 24:677~682
Kahn SR / 2012 / Prevention of VTE in nonsurgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines / Chest 141:e195S~e226S
Alhazzani W / 2013 / Heparin thromboprophylaxis in medical-surgical critically ill patients : a systematic review and meta-analysis of randomized trials / Crit Care Med 41:2088~2098
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