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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 69 - 75 (7page)
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The potential of using chitosan as a biological agent for the control of Candida albicans was investigated. A chitosan designated as an active molecular chitosan (AMC) with average molecular weight of 8.5-kDa exhibited an effective and potential anticandidal effect at 100 mg/mL. Although metal ion Zn 2+ and EDTA had shown the significant growth inhibitory activity, but both had also shown the static effect on reversible growth inhibition, respectively, whereas AMC showed irreversible growth inhibition. In addition, anticandidal activity of those metal ions, chelating agent and a classic drug using as anticandidal agent Amphotericin B was greatly increased in the presence of AMC mg/mL. These results suggest that AMC-Zn 2+ - EDTA exerted their activities through dysregulation of the homeostasis or signaling of different cations in anticandidal effect. Thus, the combination of Zn 2+ , chelating agent EDTA and AMC may be an effective disease management strategy to prevent or delay the development of bactericidal-resistant strains.
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참고문헌 (26)
참고문헌 신청
Croce, M. / 2016 / Synthesis and screening of N-acyl thiolated chitosans for antibacterial applications / Carbohydr. Polym 151:1184~1192
Jarmila, V. / 2011 / Chitosan derivatives with antimicrobial, antitumour and antioxidant activities - A review / Curr. Pharm. Des 17:3596~3607
Li, J. / 2016 / Antibacterial activity and mechanism of chitosan with ultra high molecular weight / Carbohydr. Polym 148:200~205
Chang-Suk Kong / 2010 / Antiproliferative Effect of Chitosan-Added Kimchi in HT-29 Human Colon Carcinoma Cells / Journal of Medicinal Food 13(1):6~12
Muanprasat, C. / 2016 / Chitosan oligosac-charide: Biological activities and potential therapeutic applications / Pharmacol. Ther
Jarmila, V. / 2011 / Chitosan derivatives with antimicrobial, antitumour and antioxidant activities - A review / Curr. Pharm. Des 17:3596~3607
Li, J. / 2016 / Antibacterial activity and mechanism of chitosan with ultra high molecular weight / Carbohydr. Polym 148:200~205
Chang-Suk Kong / 2010 / Antiproliferative Effect of Chitosan-Added Kimchi in HT-29 Human Colon Carcinoma Cells / Journal of Medicinal Food 13(1):6~12
Muanprasat, C. / 2016 / Chitosan oligosac-charide: Biological activities and potential therapeutic applications / Pharmacol. Ther
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