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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 266 - 276 (11page)
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이 논문의 연구 히스토리 (2)
2018
Association of serum mineral parameters with mortality in hemodialysis patients : Data analysis from Korean end-stage renal disease registry
김윤미
의학과
2018.01
학위논문
Association of serum mineral parameters with mortality in hemodialysis patients: Data from the Korean endstage renal disease registry
김윤미
,
유경돈
,
김효진
외 10명
Kidney Research and Clinical Practice
2018.01
학술저널
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초록· 키워드
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Background: We investigated the associations between mineral metabolism parameters and mortality to identify optimal targets in Korean hemodialysis patients. Methods: Among hemodialysis patients registered in the end-stage renal disease registry of the Korean Society of Nephrology between March 2012 and June 2017, those with serum calcium, phosphorus, and intact parathyroid hormone (iPTH) measured at enrollment were included. Association of serum levels of calcium, phosphorus, and iPTH with all-cause mortality was analyzed. Results: Among 21,433 enrolled patients, 3,135 (14.6%) died during 24.8 ± 14.5 months of follow-up. After multivariable adjustment, patients in the first quintile of corrected calcium were associated with lower mortality (hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.71-0.99; P = 0.003), while those in the fifth quintile were associated with higher mortality (HR, 1.39; 95% CI, 1.20-1.61; P < 0.001) compared with those in the third quintile. For phosphorus, only the lowest quintile was significantly associated with increased mortality (HR, 1.24; 95% CI, 1.08-1.43; P = 0.003). The lowest (HR, 1.18; 95% CI, 1.02-1.36; P = 0.026) and highest quintiles of iPTH (HR, 1.24; 95% CI, 1.05-1.46; P = 0.013) were associated with increased mortality. For target counts achieved according to the Kidney Disease Outcomes Quality Initiative guideline, patients who did not achieve any mineral parameter targets hadhigher mortality than those who achieved all three targets (HR, 1.37; 95% CI, 1.12-1.67; P = 0.003). Conclusion: In Korean hemodialysis patients, high serum calcium, low phosphorus, and high and low iPTH levels were associated with increased all-cause mortality.
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참고문헌 (24)
참고문헌 신청
2009 / Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKDMBD) / Kidney Int Suppl 113:S1~S130
Wheeler DC / 2017 / KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD) / Kidney Int Suppl 7:1~59
Naylor KL / 2014 / The three-year incidence of fracture in chronic kidney disease / Kidney Int 86:810~818
Vervloet MG / 2017 / The role of phosphate in kidney disease / Nat Rev Nephrol 13:27~38
Tentori F / 2008 / Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS) / Am J Kidney Dis 52:519~530
Wheeler DC / 2017 / KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD) / Kidney Int Suppl 7:1~59
Naylor KL / 2014 / The three-year incidence of fracture in chronic kidney disease / Kidney Int 86:810~818
Vervloet MG / 2017 / The role of phosphate in kidney disease / Nat Rev Nephrol 13:27~38
Tentori F / 2008 / Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS) / Am J Kidney Dis 52:519~530
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