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논문 기본 정보

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학술저널
저자정보
Muhammad A. Siddiqui (Saskatchewan Health Authority) Suhel Ashraff (Royal Victoria Infirmary) Derek Santos (Queen Margaret University) Robert Rush (Queen Margaret University) Thomas Carline (Queen Margaret University) Zahid Raza (Royal Infirmary)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.37 No.3
발행연도
2018.1
수록면
277 - 286 (10page)

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초록· 키워드

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Background: The objevctive of the present study was to explore the potential influence of blood markers and patient factors such as risk factors, kidney function profile, coagulation profile, lipid profile, body mass index, blood pressure, and vein diameter on the maturation of arteriovenous fistula (AVF) in patients with end-stage renal disease. Methods: Retrospective data from 300 patients who had undergone AVF creation at the Royal Infirmary of Edinburgh were examined. A predictive logistic regression model was developed using a backward stepwise procedure. Model performance, discrimination, and calibration were assessed using the receiver operating characteristic (ROC) curve and Hosmer-Lemeshow goodness-of-fit test. The final model was externally validated by 100 prospective patients who received a new fistula at the Royal Infirmary of Edinburgh. Results: A total of 400 (300 retrospective and 100 prospective) patients were recruited for this study, with a mean age of 60.14 ± 15.9 years (development set) and 58 ± 15 years (validation set), respectively (P = 0.208). Study results showed that males were twice as likely to undergo fistula maturation as females, while patients with no evidence of peripheral vascular disease (PVD) were three times more likely to mature their fistula and a preoperative vein diameter > 2.5 mm resulted in a fivefold increase in fistula maturation as compared with a vein size of less than 2.5 mm. The model for fistula maturation had fair discrimination, as indicated by the area under the ROC curve (0.68), but good calibration as indicated by the Hosmer-Lemeshow test (P = 0.79). The area under the receiver operating curve for the validation model in the validation set was 0.59. Similarly, in the validation set, the Hosmer-Lemeshow statistic indicated an agreement between the observed and predicted probabilities of maturation (P > 0.05). Conclusion: Gender, PVD, and vein size are independent predictors of AVF maturation. The clinical utility of these risk categories in the maturation of AVF requires further evaluation in longer follow-up.

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참고문헌 (40)

참고문헌 신청
Levey AS / 2007 / Chronic kidney disease: common, harmful, and treatable--World Kidney Day 2007 / J Am Soc Nephrol 18:374~378 Crossref NHS Digital / Quality and outcomes framework - prevalence, achievements and exceptions report, England 2015-16 google schola MacNeill SJ / 2016 / UK renal registry 18th annual report: chapter 2 UK renal replacement therapy prevalence in 2014: national and centre-specific analyses / Nephron 132(Suppl 1):41~68 Crossref Dhoul N / 2012 / Quality achievement and disease prevalence in primary care predicts regional variation in renal replacement therapy (RRT) incidence: an ecological study / Nephrol Dial Transplant 27:739~746 Crossref Allon M / 2007 / Current management of vascular access / Clin J Am Soc Nephrol 2:786~800 Crossref

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