지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 84 - 91 (8page)
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초록· 키워드
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Background: This study examined the outcomes of ABO incompatible living donor liver transplantation (LDLT). The changes in the immunologic factors that might help predict the long term outcomes were also studied. Methods: Twenty-three patients, who underwent ABO incompatible LDLT from 2010 to 2015, were reviewed retrospectively. The protocol was the same as for ABO compatible LDLT except for the administration of rituximab and plasma exchange. The clinical outcomes and immunologic factors, such as isoagglutinin titer and cluster of differentiation 20+ (CD20+) lymphocyte levels were reviewed. Results: The center showed a 3-year survival of 64% with no case of antibody-mediated rejection. When transplantation-unrelated mortalities (for example, traffic accidents and myocardial infarction) were removed from statistical analysis, the 3-year survival was 77.8%. Although isoagglutinin titers continued to remain at low levels, the CD20+ lymphocyte levels recovered to the pre-Rituximab levels at postoperative one year. Conclusions: As donor shortages continue, ABO incompatible liver transplantation is a feasible method to expand the donor pool. On the other hand, caution is still needed until more long-term outcomes are reported. Because CD20+ lymphocytes are recovered with time, more immunologic studies will be needed in the future.
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참고문헌 (18)
참고문헌 신청
Starzl TE / 1979 / Fifteen years of clinical liver transplantation / Gastroenterology 77:375~388
Gugenheim J / 1990 / Liver transplantation across ABO blood group barriers / Lancet 336:519~523
Rego J / 1987 / Hyperacute rejection after ABO-incompatible orthotopic liver transplantation / Transplant Proc 19:4589~4590
Monteiro I / 2003 / Rituximab with plasmapheresis and splenectomy in abo-incompatible liver transplantation / Transplantation 76:1648~1649
Stewart ZA / 2009 / ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis / Liver Transpl 15:883~893
Gugenheim J / 1990 / Liver transplantation across ABO blood group barriers / Lancet 336:519~523
Rego J / 1987 / Hyperacute rejection after ABO-incompatible orthotopic liver transplantation / Transplant Proc 19:4589~4590
Monteiro I / 2003 / Rituximab with plasmapheresis and splenectomy in abo-incompatible liver transplantation / Transplantation 76:1648~1649
Stewart ZA / 2009 / ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis / Liver Transpl 15:883~893
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