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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 11 (11page)
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Objective: The aim of this study was to evaluate the diagnostic value of integrated 18F-fluoro-2-deoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) for suspected recurrence of epithelial ovarian cancer (EOC) with non-disseminated lesions. Methods: We retrospectively reviewed the medical records of recurrent EOC patients who underwent secondary cytoreduction from January 2000 to December 2013. A total of 134 patients underwent secondary cytoreduction after imaging with either 18F-FDG-PET/CT or contrast-enhanced computed tomography (CECT). Results: In a patient-based analysis of 134 patients, 124 (92.5%) were confirmed to be positive for malignancy. Among 72 patients with suspected non-disseminated recurrence on 18F-FDG-PET/CT, 65 (89.0%) were confirmed to have recurrence, giving 98.5% sensitivity, 87.7% accuracy, and 88.9% positive predictive value (PPV). In the 65 patients with recurrence, residual tumor remained in 14 patients, giving an accuracy of patient selection for secondary cytoreduction of 69.4% (50/72) and it is higher than that of CECT (64.0%). In 169 lesions removed from patients who underwent preoperative 18F-FDG-PET/CT, 135 (79.9%) were confirmed to be positive for malignancy and 124 were accurately detected by 18F-FDG-PET/CT, giving 91.9% sensitivity, 81.1% accuracy, and 85.5% PPV. Foreign body granuloma was found in 33.3% of 21 lesions with false-positive 18F-FDG-PET/CT findings (7/21). The mean preoperative cancer antigen 125 (CA-125) level in false-positive patients was 28.8 U/mL. Conclusion: Compared with CECT, 18F-FDG-PET/CT shows higher sensitivity in lesion-based analysis and better accuracy of patient selection for secondary cytoreduction. However, there is still a need for integration of the results of 18F-FDG-PET/CT, CECT, and CA-125 levels to aid treatment planning.
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참고문헌 (25)
참고문헌 신청
Siegel R / 2013 / Cancer statistics, 2013 / CA Cancer J Clin 63:11~30
Damak T / 2012 / Results of second-look laparotomy in advanced ovarian cancer: one single center experience / ISRN Obstet Gynecol 2012:849518
Thrall MM / 2007 / Clinical use of combined positron emission tomography and computed tomography (FDG-PET/CT) in recurrent ovarian cancer / Gynecol Oncol 105:17~22
Niloff JM / 1986 / The CA 125 assay as a predictor of clinical recurrence in epithelial ovarian cancer / Am J Obstet Gynecol 155:56~60
Hogberg T / 1992 / Long-term follow-up of ovarian cancer with monthly determinations of serum CA 125 / Gynecol Oncol 46:191~198
Damak T / 2012 / Results of second-look laparotomy in advanced ovarian cancer: one single center experience / ISRN Obstet Gynecol 2012:849518
Thrall MM / 2007 / Clinical use of combined positron emission tomography and computed tomography (FDG-PET/CT) in recurrent ovarian cancer / Gynecol Oncol 105:17~22
Niloff JM / 1986 / The CA 125 assay as a predictor of clinical recurrence in epithelial ovarian cancer / Am J Obstet Gynecol 155:56~60
Hogberg T / 1992 / Long-term follow-up of ovarian cancer with monthly determinations of serum CA 125 / Gynecol Oncol 46:191~198
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