지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.5 No.6
- 발행연도
- 2013.1
- 수록면
- 343 - 347 (5page)
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초록· 키워드
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My research career has focused on the causes of asthma and its treatment. After establishing the key role that mast cells play in the inflammatory response in asthma, attention was turned towards understanding disease chronicity and variability across the lifecourse. Through a combination of studies on airway biopsies and primary cell cultures we have established that asthma is primarily an epithelial disease driven by increased environmental susceptibility to injury and an altered repair response as depicted by sustained activation of the epithelial mesenchymal trophic unit (EMTU) that is invoked in foetal branching morphogenesis. Varied activation of the EMTU connects the origins of asthma to its progression over time with involvement of epithelial susceptibility through impaired barrier and innate immune functions and altered mesenchymal susceptibility as exemplified by polymorphisms of the metalloprotease gene, ADAM33. Taken together these observations have led to a fundamental re-evaluation of asthma pathogenesis. Rather than placing allergic inflammation as the prime abnormality, it is proposed that the airway epithelium lies at the center of asthma pathogenesis, and that in conjunction with the underlying mesenchyme, it is the principle orchestrator of both the induction of asthma and its evolution over the lifecourse. This concept has provided 'the basis for a new preventative and therapeutic approach focused more on increasing the airways resistance to environmental insults rather than suppressing downstream inflammation once it is established.
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참고문헌 (21)
참고문헌 신청
Holgate ST / 1977 / Beta-adrenergic agonist resistance in normal human airways / Lancet 2:375~377
Howarth PH / 1985 / Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma / Am Rev Respir Dis 132:986~992
Cushley MJ / 1983 / Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects / Br J Clin Pharmacol 15:161~165
Bradding P / 1992 / Interleukin 4 is localized to and released by human mast cells / J Exp Med 176:1381~1386
Montefort S / 1994 / Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways / J Clin Invest 93:1411~1421
Howarth PH / 1985 / Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma / Am Rev Respir Dis 132:986~992
Cushley MJ / 1983 / Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects / Br J Clin Pharmacol 15:161~165
Bradding P / 1992 / Interleukin 4 is localized to and released by human mast cells / J Exp Med 176:1381~1386
Montefort S / 1994 / Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways / J Clin Invest 93:1411~1421
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