지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,055 - 1,061 (7page)
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This study evaluated the incidence of hepatic toxicity after stereotactic ablative radiotherapy (SABR) using 3 fractions to the liver, and identified the predictors for hepatic toxicity. We retrospectively reviewed 78 patients with primary and metastatic liver cancers, who underwent SABR using 3 fractions between 2003 and 2011. To examine the incidence of hepatic toxicity, we defined newly developed hepatic toxicity ≥ grade 2 according to the National Cancer Institute Common Terminology Criteria for Adverse Events v4.0 within 3 months after the end of SABR as a significant adverse event. To identify the predictors for hepatic toxicity, we analyzed several clinical and dosimetric parameters (rV5Gy-rV35Gy: normal liver volume receiving < X Gy, reverse VXGy). Hepatic toxicity ≥ grade 2 occurred in 10 patients (13%): grade 2 in 9 patients and grade 3 in 1 patient. On univariate analysis, baseline Child-Pugh (CP) score (5 vs. 6-8), normal liver volume, and planning target volume were the significant clinical predictors. All dosimetric parameters were significant: rV20Gy was the most significant predictor. On multivariate analysis, baseline CP score (hazard ratio, 0.026; P = 0.001) was the only significant predictor. In conclusion, SABR using 3 fractions in primary and metastatic liver cancers produces low hepatic toxicity, especially in patients with a baseline CP score of 5. However, further studies are needed to minimize hepatic toxicity in patients with baseline CP scores ≥ 6.
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참고문헌 (31)
참고문헌 신청
Ingold JA / 1965 / Radiation Hepatitis / Am J Roentgenol Radium Ther Nucl Med 93:200~208
Reed GB Jr / 1966 / The human liver after radiation injury. A form of veno-occlusive disease / Am J Pathol 48:597~611
Lawrence TS / 1995 / Hepatic toxicity resulting from cancer treatment / Int J Radiat Oncol Biol Phys 31:1237~1248
Pan CC / 2010 / Radiation-associated liver injury / Int J Radiat Oncol Biol Phys 76:S94~S100
Potters L / 2004 / American Society for Therapeutic Radiology and Oncology and American College of Radiology practice guideline for the performance of stereotactic body radiation therapy / Int J Radiat Oncol Biol Phys 60:1026~1032
Reed GB Jr / 1966 / The human liver after radiation injury. A form of veno-occlusive disease / Am J Pathol 48:597~611
Lawrence TS / 1995 / Hepatic toxicity resulting from cancer treatment / Int J Radiat Oncol Biol Phys 31:1237~1248
Pan CC / 2010 / Radiation-associated liver injury / Int J Radiat Oncol Biol Phys 76:S94~S100
Potters L / 2004 / American Society for Therapeutic Radiology and Oncology and American College of Radiology practice guideline for the performance of stereotactic body radiation therapy / Int J Radiat Oncol Biol Phys 60:1026~1032
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