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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 229 - 235 (7page)
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초록· 키워드
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Neurodegenerative diseases are the hereditary and sporadic conditions which are characterized by progressive neuronal degeneration. Neurodegenerative diseases are emerging as the leading cause of death, disabilities, and a socioeconomic burden due to an increase in life expectancy. There are many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis, but we have no effective treatments or cures to halt the progression of any of these diseases. Stem cell-based therapy has become the alternative option to treat neurodegenerative diseases. There are several types of stem cells utilized; embryonic stem cells, induced pluripotent stem cells, and adult stem cell (mesenchymal stem cells and neural progenitor cells). In this review, we summarize recent advances in the treatments and the limitations of various stem cell technologies. Especially, we focus on clinical trials of stem cell therapies for major neurodegenerative diseases.
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참고문헌 (80)
참고문헌 신청
Lunn JS / 2011 / Stem cell technology for neurodegenerative diseases / Ann Neurol 70:353~361
Pittenger MF / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284:143~147
Sorrentino A / 2008 / Isolation and characterization of CD146+ multipotent mesenchymal stromal cells / Exp Hematol 36:1035~1046
Tanna T / 2014 / Mesenchymal stem cells: potential in treatment of neurodegenerative diseases / Curr Stem Cell Res Ther 9:513~521
Chan TM / 2014 / ADSC therapy in neurodegenerative disorders / Cell Transplant 23:549~557
Pittenger MF / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284:143~147
Sorrentino A / 2008 / Isolation and characterization of CD146+ multipotent mesenchymal stromal cells / Exp Hematol 36:1035~1046
Tanna T / 2014 / Mesenchymal stem cells: potential in treatment of neurodegenerative diseases / Curr Stem Cell Res Ther 9:513~521
Chan TM / 2014 / ADSC therapy in neurodegenerative disorders / Cell Transplant 23:549~557
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